Results 111 to 120 of about 13,060 (191)

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 11, November 2026.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source

Metabolic marker profiling of circulating tumour cells in NSCLC patients treated with osimertinib: focus on MCT1 and MCT4

Therapeutic Advances in Medical Oncology
Background: Monocarboxylate transporters (MCTs) facilitate lactate transfer and support cancer cell survival and metastasis. MCT1 and MCT4 expression has been associated with poor prognosis and resistance to therapy with tyrosine kinase inhibitors ...
Karolina Mangani, Evangelia Pantazaka, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Athina Markou, Galatea Kallergi   +6 more
doaj   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science
As a major fuel source for the tricarboxylic acid cycle, lactate controls energy metabolism through cell‐to‐cell or tissue‐to‐tissue lactate shuttles via monocarboxylate transporters (MCTs). Although lactate is shown to influence macrophage functions via
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
doaj   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

MCT1 and CD147 interact at the plasma membrane of oxidative tumor cells.

, 2012
(A) The left graph shows basal SLC16A1/MCT1 mRNA expression normalized to RPL19 mRNA expression detected in SiHa and WiDr TCs using RT-qPCR. **p = 0.0062; n = 5–8.
Olivier Feron (126505), Pierre Sonveaux (126507), Paolo E. Porporato (126501), Julien Verrax (126503), Tamara Copetti (126499), Christophe J. De Saedeleer (126496)   +5 more
core   +1 more source

A common polymorphism of the MCT1 gene and athletic performance [PDF]

Purpose: In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. The A1470T polymorphism (rs1049434) in the MCT1 gene was shown to be associated with lactate transport rates in human ...
Mustafina, LJ, Ahmetov, II, Popov, DV, Fedotovskaya, ON, Vinogradova, OL   +4 more
core   +1 more source

Evaluation of MCT1 Inhibitors for Pancreatic Cancer [PDF]

, 2013
UROP paper, 2013, Chemistry and BiochemistryUndergraduate Research Opportunities Program, University of Minnesota DuluthLueth, Erica. (2013). Evaluation of MCT1 Inhibitors for Pancreatic Cancer.
Lueth, Erica
core  

Polymorphisms in MCT1, CD147, PDK4, and DMRT3 genes in Arabian and Quarter Horses

, 2017
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo FAPESP: 2012/24193-0Processo FAPESP: 2014/20697-9Monocarboxylate transporter isoform 1 (MCT1) and its ancillary protein, CD147 function to transport H+ and lactate ions, retarding ...
Regatieri, Inaê Cristina, Pereira, Guilherme Luis, Regatieri, Inaê Cristina [UNESP], Curi, Rogério Abdallah, Ferraz, Guilherme Camargo, Ferraz, Guilherme Camargo [UNESP], Queiroz-Neto, Antonio [UNESP], Pereira, Guilherme Luis [UNESP], Teixeira Neto, Antônio Raphael, Queiroz-Neto, Antonio, Curi, Rogério Abdallah [UNESP]   +10 more
core   +1 more source

Colocalization of mCherry-Mct1 with endosomal markers.

, 2014
Each three part panel shows a large merged image and smaller images of the corresponding color channels, where Mct1 is pseudocolored red, the counter stain appears green, and colocalization appears yellow.
Jeffrey P. Smith (509882), Micah J. Velasquez (509881), Amy L. Uhernik (509879), Nathan LaVoy (509880), Lun Li (155358)   +4 more
core   +1 more source