Results 101 to 110 of about 13,060 (191)

Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

Nature Communications
Itaconate accumulates in macrophages upon bacterial infection, and manifests antibacterial activity. Convincing evidence substantiates that itaconate is transported across the plasma membrane and vacuolar membrane, but the molecular bases underlying ...
Qingcai Meng, Chengxi Li, Yuping Cai, Ying Chen, Xiaoqing Chen, Xin Wang, Biling Zhang, Yue Zhang, Feng Liu, Meixin Chen   +9 more
doaj   +1 more source

MCT1-, MCT4- ja CD147-proteiinit kehittyvässä kilin pötsissä [PDF]

, 2012
Nuoren märehtijän alkaessa syödä kiinteää ravintoa, etumahojen suhteellinen osuus mahoista kasvaa ja niiden seinämän epiteeli alkaa kehittyä mahdollistaakseen ravintoaineiden tehokkaan imeytymisen.
Tiihonen, Heidi
core  

Relative liver mRNA expression levels for various genes involved in lipid metabolism from MCT1^+/− and MCT1^+/+ mice fed either normal chow or high fat diet.

, 2013
Quantitative RT-PCR analysis of relative mRNA levels for several genes related to lipid metabolism in liver collected from MCT1+/− and MCT1+/+ mice either fed normal chow or high fat diet for three months.
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Cancer Cell International, 2019
Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang, Yi-chong Chen   +7 more
doaj   +1 more source

Further Insights Into the Mechanisms of Lymph Node Metastasis

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Metastasis of malignant tumors arising from epithelial organs to sentinel lymph nodes has important implications for prognosis, staging, and therapeutic decision‐making. Recent insights into anatomic pathways, pathogenesis, molecular interactions, and genetic factors have encouraged scientists and clinicians to develop drugs that target ...
S. David Nathanson, Meghan J. O'Melia, Kelly C. Rosso, Ian S. Wood, Drishti Lall, Jenny T. Bui   +5 more
wiley   +1 more source

Differential expression of endothelial nutrient transporters (MCT1 and GLUT1) in the developing eyes of mice [PDF]

, 2016
The blood-brain barrier in the neonatal brain expresses the monocarboxylate transporter (MCT)-1 rather than the glucose transporter (GLUT)-1, due to the special energy supply during the suckling period. The hyaloid vascular system, consisting of the vasa
Kishimoto, Ayuko, Iwanaga, Toshihiko, Watanabe, Masahiko M, Takahashi-Iwanaga, Hiromi   +3 more
core   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Mechanistic Insights Into How Acupuncture Modulates Host Immunity via the Gut Microbiota‐Macrophage Axis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
Electroacupuncture at specific acupoints (e.g., ST36, ST25) activates somato‑vagal neural circuits via PROKR2‑expressing sensory fibers. This top‑down signal restructures the gut microenvironment by enriching beneficial symbionts (e.g., Akkermansia muciniphila) and strengthening the intestinal barrier.
Tao Yang, Mei Li, Xiaowen Wu
wiley   +1 more source

Role of the Monocarboxylate transporter 1 (MCT1) in T lymphocytes

, 2020
Upon activation, T cells shift towards a metabolic program characterized by increased glucose metabolism in order to sustain proliferation and effector function.
D'Aria, Stefania
core