Results 101 to 110 of about 10,143 (187)

Optogenetic screening of MCT1 activity implicates a cluster of non-steroidal anti-inflammatory drugs (NSAIDs) as inhibitors of lactate transport.

PLoS ONE
Lactate transport plays a crucial role in the metabolism, microenvironment, and survival of cancer cells. However, current drugs targeting either MCT1 or MCT4, which traditionally mediate lactate import or efflux respectively, show limited efficacy ...
Scott A Wegner, Hahn Kim, José L Avalos
doaj   +1 more source

Phenylalanine Versus Tyrosine (Pos. 367/332 in MCT1/MCT4) in the Substrate Binding Site Defines Affinity and Preferred Directionality of Human Monocarboxylate Transporters 1-4. [PDF]

Acta Physiol (Oxf)
Menzel M, Dumitru ID, Peters J, Hövener JB, Pravdivtsev AN, Bondar AN, Beitz E.   +6 more
europepmc   +1 more source

Lactylation landscape of mitochondrial proteins in myocardial infarction. [PDF]

Redox Biol
Kadam A, Kashyap S, Samantaray K, Jaiswal N, Goyani S, Kramer PA, Hadi P, Lee J, Furdui CM, Jadiya P, Tomar D.   +10 more
europepmc   +1 more source

Lactate Dehydrogenase B Expression in Cerebellum of Adult <i>Ube3a</i> ^m-/p+ Mice. [PDF]

MicroPubl Biol
Ramos Rivera MA, Torres Ortiz C.
europepmc   +1 more source

Targeting metabolic dependencies to reverse chemoradiotherapy resistance in colorectal cancer. [PDF]

J Exp Clin Cancer Res
Hellkamp M, Gertken S, Buchloh J, Hellwig JL, Kowitzke LB, Duan N, Gaspardo I, Küffer S, Linnebacher M, Ströbel P, Wirth M, Ellenrieder V, Rieken S, Gaedcke J, Ghadimi M, Wienands J, Schneider G, Spitzner M, Grade M.   +18 more
europepmc   +1 more source

Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. [PDF]

Development
Guertin TM, Sisson C, Gargiulo RM, Macrorie O, Pease EL, Garth HE, Vriens J, De Clercq K, Mager J, Tremblay KD.   +9 more
europepmc   +1 more source

Astragaloside IV represses the immune evasion and acidic microenvironment of oral squamous cell carcinoma. [PDF]

Cell Mol Biol Lett
Zhao W, Zheng H, Chang Y, Shang T, Wang L, Liu J, Deng J, Pan Z, Hu X, Huang X, Cui Y.   +10 more
europepmc   +1 more source

Metabolic Reprogramming-Driven Lactylation: Emerging Mechanisms Linking DNA Damage Repair and Chemoresistance in Cancer. [PDF]

Cells
Wang L, Zhong S, Zhao J, Liu L, Li C.
europepmc   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics. [PDF]

Clin Transl Med
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S.   +5 more
europepmc   +1 more source

Clinical implications of lactylation modification in digestive system tumors (Review). [PDF]

Oncol Lett
Pan L, Liu F, Yu W.
europepmc   +1 more source