Results 81 to 90 of about 13,060 (191)
Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts
Cell Proliferation, EarlyView.Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu +8 more
wiley +1 more source
Lactate and Lactylation: What We Know and What We Expect in Tumour Progression
Cell Proliferation, EarlyView.Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley +1 more source
Expression and correlation of MCT1 and MCT4 in ccRCC.
, 2018 (A and C) Positive membranous staining to MCT1 and MCT4 in primary ccRCCs at high magnification (x100). (B and D) Heterogenous membranous staining to MCT1 and MCT4 in a tumor at low magnification (x20).
Nathalie Rioux-Leclercq (249571) +10 more
core +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Propionate in the fetal circulation is thought to originate from fermentation of dietary fibre by the maternal gut microbiota. However, the mechanism of transplacental transport has remained unclear. Here, we measured propionate permeability using a placental barrier model generated by differentiating human placental trophoblast ...
Toshiaki Tsuchitani +8 more
wiley +1 more source
Knockdown of Mct1 in the arcuate nucleus increases food-anticipatory activity in mice
Frontiers in PhysiologyAnimals rely on internal time-keeping mechanisms to anticipate regular events such as feeding, allowing preemptive gene expression which enables timely physiological responses. A manifestation of anticipatory mechanisms is also a rise in body temperature
Tomaz Martini +2 more
doaj +1 more source
Journal of Neuroinflammation, 2019 Background Microglia, the resident macrophages of central nervous system, have been initially categorized into two opposite phenotypes: classical activation related to pro-inflammatory responses and alternative activation corresponding with anti ...
Liang Kong +5 more
doaj +1 more source
Frontiers in Pediatrics, 2019 The solute carrier family 16 member 1 (SLC16A1) gene encodes for monocarboxylate transporter 1 (MCT1) that mediates the movement of monocarboxylates, such as lactate and pyruvate across cell membranes.
Sara Al-Khawaga +12 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
, 2020 Metabolite exchange between stromal and tumor cells or among tumor cells themselves accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma (PDAC).
Alexander Arlt +6 more
core +1 more source