Results 121 to 130 of about 13,060 (191)

Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

Molecular Medicine
Background The terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metabolic disturbances in cardiomyocytes.
Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li, Tianhui Wang   +10 more
doaj   +1 more source

Evaluation of MCT1 and MCT4 in ovarian carcinomas: quantitative estimation and digital image analysis compared in the study of metabolic markers

, 2023
reservedIntroduzione: I carcinomi ovarici rappresentano il 30% dei tumori dell’apparato genitale femminile e circa il 60% di tutti i tumori ovarici; tra questi il più frequente è il carcinoma sieroso di alto grado (70% dei carcinomi ovarici) il cui ...
FANIN, GIULIA
core  

Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity

, 2016
Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS).
Eichner, Ruth;Heider, Michael;Fernández-Sáiz, Vanesa;van Bebber, Frauke;Garz, Anne-Kathrin;Lemeer, Simone;Rudelius, Martina;Targosz, Bianca-Sabrina;Jacobs, Laura;Knorn, Anna-Maria;Slawska, Jolanta;Platzbecker, Uwe;Germing, Ulrich;Langer, Christian;Knop, Stefan;Einsele, Herrmann;Peschel, Christian;Haass, Christian;Keller, Ulrich;Schmid, Bettina;Götze, Katharina S;Kuster, Bernhard;Bassermann, Florian
core   +1 more source

MCT1 as a critical regulator of insulin signaling, energy homeostasis and podocyte function

Scientific Reports
Podocytes are highly specialized epithelial cells that play a central role in maintaining integrity of the glomerular filtration barrier. Because of their complex architecture and dynamic actin-based cytoskeleton, podocytes have substantial energy ...
Maria Szrejder, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Agnieszka Piwkowska   +4 more
doaj   +1 more source

Monocarboxylate transporter 1 (MCT1) promotes tumor metastasis independently of its activity as a transporter of lactate

, 2018
Metastasis is of poor prognosis for cancer patients as it marks the transition between a localized and a systemic disease, thus limiting therapeutic opportunities for cancer cure.
Vazeille, Thibaut, Radecke, KS, Bouzin, Caroline, Payen, Valéry, Sonveaux, Pierre, Hsu, MY, Wyart, E, Porporato, Paolo E, ISCaM2018   +8 more
core  

A basigin antibody modulates MCTs to impact tumor metabolism and immunity

Cell Discovery
Lactate metabolism and signaling intricately intertwine in the context of cancer and immunity. Basigin, working alongside monocarboxylate transporters MCT1 and MCT4, orchestrates the movement of lactate across cell membranes.
Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao   +16 more
doaj   +1 more source

Primary tumor-derived lactate primes prostate cancer cells for a dormant fate. [PDF]

Sci Adv
Ippolito L, Pranzini E, Gangarossa G, Iozzo M, Comito G, Venditti G, Roccabianca S, Pardella E, Lulli M, Santi A, Nesi G, Giannoni E, Chiarugi P.   +12 more
europepmc   +1 more source

Data from MCT1 Inhibition Remodels the Tumor Immune Microenvironment for Enhanced Cancer Immunotherapy

<div>Abstract<p>Despite advances in cancer immunotherapies such as immune checkpoint blockade (ICB), durable patient responses remain constrained, which is largely due to the highly suppressive tumor immune microenvironment (TIME).
Fuxin Han, Yelei Guo, Yao Wang, Weidong Han, Chuan Tong, Chun Liu, Yipeng Zhang, Yuting Lu   +7 more
core   +1 more source

Monocarboxylate Transporter 1 (MCT1) in Cancer Biology: Canonical Transport Functions, Metabolic-Epigenetic Crosstalk and Emerging Nuclear Localisation. [PDF]

Cancers (Basel)
Franczak J, Latif A.
europepmc   +1 more source

GPR81 Regulates MCT1 Membrane Translocation Through a PKA-Dependent Signaling Pathway in Rat Podocytes. [PDF]

Int J Mol Sci
Grochowalska K, Szrejder M, Audzeyenka I, Piwkowska A.   +3 more
europepmc   +1 more source