Results 21 to 30 of about 113,465,300 (217)

Monocarboxylate Transporter-1 Is Dispensable for Hepatocellular Carcinoma Development. [PDF]

Mol Carcinog
ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer and the deadliest liver disease. It is imperative to understand the underlying molecular mechanisms involved in the development of HCC. Monocarboxylate transporter‐1 (MCT1) is a proton‐coupled protein that facilitates the bidirectional transport of monocarboxylates, such ...
Gad SA, Bridgeman B, Boedeker K, Ding X, Qiu W.   +4 more
europepmc   +3 more sources

Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer [PDF]

Cancers, 2021
Background: Monocarboxylate transporters (MCTs) appear to play an important role in tumor development and aggressiveness. The present study aimed to evaluate associations between cytoplasmic MCT1, MCT4, and mitochondrial cytochrome c oxidase (MTCO1) expression and clinicopathological variables or survival in gastric cancer.
Kauppila Joonas, Eskuri Maarit Janita, Kemi Niko Aleksi   +2 more
openaire   +3 more sources

Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965. [PDF]

Cancers (Basel), 2020
The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. We aimed to investigate nutrient fluxes associated with MCT1 inhibition by AZD3965 to identify possible biomarkers of drug action.
Braga M, Kaliszczak M, Carroll L, Schug ZT, Heinzmann K, Baxan N, Benito A, Valbuena GN, Stribbling S, Beckley A, Mackay G, Mauri F, Latigo J, Barnes C, Keun H, Gottlieb E, Aboagye EO.   +16 more
europepmc   +6 more sources

Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis

Journal of Biomedical Science, 2022
Background Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic drug and a histone deacetylase ...
Asmita Gyawali, Sana Latif, Seung-Hye Choi, Seung Jae Hyeon, Hoon Ryu, Young-Sook Kang   +5 more
doaj   +1 more source

Creatineおよび creatine 前駆体の排出輸送におけるmonocarboxylate transporter 12の役割解明 [PDF]

, 2023
富山大学博士（薬科学）Article富山大学・富医薬博甲第425号・定村 龍太・2023/03/23 公表論文 1.Jomura R, Tanno Y, Akanuma SI, Kubo Y, Tachikawa M, Hosoya KI. Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells. Biochim Biophys
定村, 龍太
core   +1 more source

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

Haematologica, 2017
Inhibition of monocarboxylate transporter 1 has been proposed as a therapeutic approach to perturb lactate shuttling in tumor cells that lack monocarboxylate transporter 4.
Richard A. Noble, Natalie Bell, Helen Blair, Arti Sikka, Huw Thomas, Nicole Phillips, Sirintra Nakjang, Satomi Miwa, Rachel Crossland, Vikki Rand, Despina Televantou, Anna Long, Hector C. Keun, Chris M. Bacon, Simon Bomken, Susan E. Critchlow, Stephen R. Wedge   +16 more
doaj   +1 more source

Uptake and Advanced Therapy of Butyrate in Inflammatory Bowel Disease

Immuno, 2022
The pathogenesis and refractory nature of inflammatory bowel disease (IBD) are related to multiple factors, including genetic factors, environmental factors, and abnormalities in gut microbial diversity, which lead to decreased levels of short-chain ...
Shinji Ota, Hirotake Sakuraba
doaj   +1 more source

Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice [PDF]

, 2013
Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay.
Laurence S Loubière, Visser, Theo, Whitley G.S., Elisavet Vasilopoulou (420760), Loubière Laurence S., Darras, V.M. (Veerle), Loubière L.S., Darras, VM, Kilby, MD, Trajkovic-Arsic, M. (Marija), Christopher J McCabe, Guy S Whitley, Heike Heuer (420762), Heuer, H, Marija Trajkovic-Arsic, Guy S. Whitley (420764), Visser T.J., McCabe, Christopher, Gendie E. Lash (420763), Visser Theo J., Theo J. Visser (280338), Marija Trajkovic-Arsic (155746), Kilby, Mark, Franklyn, J.A. (Jayne), Mark D. Kilby (420766), Loubière, LS, Trajkovic-Arsic, M, Lash G.E., Loubière, L.S. (Laurence), Whitley Guy S., Darras, Veerle, Jayne A Franklyn, Christopher J. McCabe (420765), Loubière, Laurence, Heuer Heike, Darras V.M., Jayne A. Franklyn (236549), Whitley, Guy, Lash, G.E. (Gendie), Franklyn, Jayne, Gendie E Lash, Whitley, GS, Vasilopoulou, E, McCabe, CJ, Franklyn Jayne A., Franklyn J.A., Shiao Y Chan, Visser, TJ, Chan, SY, Veerle M Darras, Chan, Shiao, Elisavet Vasilopoulou, Heuer H., Vasilopoulou, Elisavet, Vasilopoulou Elisavet, Heuer, Heike, Lash Gendie E., Visser, T.J. (Theo), Heike Heuer, Shiao Y. Chan (420767), McCabe, C.J. (Christopher), Lash, GE, Chan S.Y., Vasilopoulou, E. (Elisavet), Kilby, M.D. (Mark), Trajkovic-Arsic M., Veerle M. Darras (104459), Heuer, H. (Heike), Chan, S.Y. (Shiao), Laurence S. Loubière (420761), McCabe Christopher J., Whitley, G.S. (Guy), Mark D Kilby, Darras Veerle M., McCabe C.J., Trajkovic-Arsic, Marija, Kilby Mark D., Franklyn, JA, Trajkovic-Arsic Marija, Chan Shiao Y., Lash, Gendie, Vasilopoulou E., Theo J Visser, Kilby M.D.   +83 more
core   +1 more source

Structure and function of a monocarboxylate transporter homolog specific for L-lactate. [PDF]

, 2019
Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor.
Dimitrios Fotiadis, Kalbermatter, David, David Kalbermatter, Patrick D. Bosshart, Bonetti, Sara, Fotiadis, Dimitrios, Bosshart, Patrick, Sara Bonetti, Bosshart PD, Bonetti S, Kalbermatter D, Fotiadis D   +11 more
core   +2 more sources

Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat [PDF]

, 2004
PURPOSE.
Layton, Christopher J., Casson, Robert J., Chidlow, Glyn, Osborne, Neville N., Wood, John P. M., Graham, Mark   +5 more
core   +1 more source