Results 21 to 30 of about 12,791 (189)
Journal of Biomedical Science, 2022 Background Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic drug and a histone deacetylase ...
Asmita Gyawali +5 more
doaj +1 more source
Haematologica, 2017 Inhibition of monocarboxylate transporter 1 has been proposed as a therapeutic approach to perturb lactate shuttling in tumor cells that lack monocarboxylate transporter 4.
Richard A. Noble +16 more
doaj +1 more source
Uptake and Advanced Therapy of Butyrate in Inflammatory Bowel Disease
Immuno, 2022 The pathogenesis and refractory nature of inflammatory bowel disease (IBD) are related to multiple factors, including genetic factors, environmental factors, and abnormalities in gut microbial diversity, which lead to decreased levels of short-chain ...
Shinji Ota, Hirotake Sakuraba
doaj +1 more source
Cancer Cell International, 2019 Background The Warburg effect demonstrates the importance of glycolysis in the development of primary and metastatic cancers. We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential transporters of lactate, in renal ...
Chen Guo +9 more
doaj +1 more source
Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
doaj +1 more source
Monocarboxylate Transporters 1 and 4 and Prognosis in Small Bowel Neuroendocrine Tumors
Cancers, 2022 Monocarboxylate transporters (MCTs) are cell membrane proteins transporting lactate, pyruvate, and ketone bodies across the plasma membrane. The prognostic role of MCTs in neuroendocrine tumors is unknown. We aimed to analyze MCT1 and MCT4 expression in small bowel neuroendocrine tumors (SB-NETs).
Niko Hiltunen +6 more
openaire +3 more sources
The Iraqi Journal of Medical Sciences, 2019 Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider F. Jawad +2 more
doaj +6 more sources
The role of the genetic factor of lactate transport in endurance sports
Здоров’я, спорт, реабілітаціяBackground and purpose With the growth of sports results, more and more attention is paid to identifying the role of genetic factors in various metabolic processes. One of these factors is the protein responsible for the transport of lactate.
Rafia Fathi +4 more
doaj +3 more sources
Protocol to evaluate the impact of murine MCT1-deficient CD8+ T cells on adipogenesis
STAR Protocols, 2023 Summary: The infiltration of activated T cells, such as CD8+ effector, in metabolic tissues plays a crucial role for the initiation and propagation of obesity-induced inflammation. Given the pivotal role of lactate transporter monocarboxylate transporter
Chiara Macchi +3 more
doaj +1 more source
Soshum: Jurnal Sosial dan Humaniora, 2021 To identify the genetic diversity of futsal players in Al Hilla Sports Club for the season (2020-2021) after they were exposed to physical exertion by testing lactic mlss in the speed of recovery and elimination of lactic acid.
Mustafa Jassim Abd Zaed +2 more
doaj +1 more source