Results 31 to 40 of about 12,791 (189)

Short-chain fatty acids in diseases

Cell Communication and Signaling, 2023
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium ...
Dan Zhang, Yong-Ping Jian, Yu-Ning Zhang, Yao Li, Li-Ting Gu, Hui-Hui Sun, Ming-Di Liu, Hong-Lan Zhou, Yi-Shu Wang, Zhi-Xiang Xu   +9 more
doaj   +1 more source

Exercise-induced hyperinsulinism: genetic basis and clinical management

中国当代儿科杂志
Exercise-induced hyperinsulinism, also known as monocarboxylate transporter 1 hyperinsulinemia, is a rare subtype of congenital hyperinsulinism caused by gain-of-function variants in the SLC16A1 gene, which encodes monocarboxylate transporter 1.
ZHANG Qi-Ting, HOU Ling
doaj   +1 more source

Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

Clinical and Translational Science, 2021
This study determined absolute transporter protein abundances in isolated microvessels of human noncancerous cerebral cortex as well as brain metastases of patients with lung and breast cancer, using a validated targeted proteomics approach.
Xun Bao, Jianmei Wu, Jun Jiang, An‐Chi Tien, Nader Sanai, Jing Li   +5 more
doaj   +1 more source

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Cell Reports, 2021
Summary: Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate and pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1).
Thomas Philips, Yevgeniya A. Mironova, Yan Jouroukhin, Jeannie Chew, Svetlana Vidensky, Mohamed H. Farah, Mikhail V. Pletnikov, Dwight E. Bergles, Brett M. Morrison, Jeffrey D. Rothstein   +9 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF MONOCARBOXYLATE TRANSPORTER 1&4 IN TANYCYTE–LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM

The Iraqi Journal of Medical Sciences, 2019
Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider Jawad, Muthanna Al-Kaabi, Anam Al-Salihi   +2 more
doaj   +1 more source

Expression of Monocarboxylate Transporter 1 (MCT1) in the Dog Intestine

Journal of Veterinary Medical Science, 2007
In this study, the expression and distribution of monocarboxyolate transporter 1 (MCT1) along the intestines (duodenum, jejunum, ileum, cecum, colon and rectum) of dogs were investigated at both the mRNA and protein levels. The expression of MCT1 protein and its distribution were confirmed by Western blotting and immunohistochemical staining using the ...
SHIMOYAMA, Yumiko, KIRAT, Doaa, AKIHARA, Yuko, KAWASAKO, Kazufumi, KOMINE, Misa, HIRAYAMA, Kazuko, MATSUDA, Kazuya, OKAMOTO, Minoru, IWANO, Hidetomo, KATO, Seiyu, TANIYAMA, Hiroyuki   +10 more
openaire   +3 more sources

Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status

Antioxidants
Beneficial effects of the microbiota-derived metabolite butyrate at the colonic level are well established, particularly through its relevance in colorectal cancer (CRC) and inflammatory bowel disease (IBD), two major intestinal pathologies.
Fátima Martel
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Monocarboxylate Transporters 1 and 4 Are Associated with CD147 in Cervical Carcinoma

Disease Markers, 2009
Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH ...
Pinheiro, Céline, Baltazar, Fátima, Longatto Filho, Adhemar, Pereira, Sónia Maria Miranda, Etlinger, Daniela, Moreira, Marise A. R., Jubé, L. F., Queiroz, Geraldo Silva, Schmitt, Fernando C.   +8 more
openaire   +3 more sources

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source