Results 51 to 60 of about 12,791 (189)

The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease

Frontiers in Immunology, 2023
Kawasaki disease (KD), an acute febrile systemic vasculitis in children, has become the leading cause of acquired heart disease in developed countries. Recently, the altered gut microbiota was found in KD patients during the acute phase.
Fangyan Wang, Fangyan Wang, Fanyu Qian, Fanyu Qian, Qihao Zhang, Qihao Zhang, Jian Zhao, Jian Zhao, Jianke Cen, Jianke Cen, Jiamin Zhang, Jiamin Zhang, Jinhui Zhou, Jinhui Zhou, Ming Luo, Ming Luo, Chang Jia, Chang Jia, Xing Rong, Xing Rong, Maoping Chu, Maoping Chu, Maoping Chu   +22 more
doaj   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

The expression pattern of butyric acid transporter in the large intestine with growth and development of suckling lambs [PDF]

Animal Bioscience
Objective The objective of this research was to explore the changes of morphological parameters, short chain fatty acid contents and butyric acid transporter expression levels in the large intestine with growth and development of sucking lambs. Methods A
Jian Ma, Tao Li, Lu Lin, Chunmei Du, Chen Wei, Fuquan Yin, Xuemei Sun, Gang Lyu, Shangquan Gan   +8 more
doaj   +1 more source

Hyperoxia induces glucose metabolism reprogramming and intracellular acidification by suppressing MYC/MCT1 axis in lung cancer

Redox Biology, 2023
The perils and promises of inspiratory hyperoxia (IH) in oncology are still controversial, especially for patients with lung cancer. Increasing evidence shows that hyperoxia exposure is relevant to the tumor microenvironment.
Xiucheng Liu, Hao Qin, Li Zhang, Caili Jia, Zhixiang Chao, Xichun Qin, Hao Zhang, Chang Chen   +7 more
doaj   +1 more source

Metabolische Untersuchungen lebender Zellen im Minutentakt, ermöglicht durch schnelle Parawasserstoff‐basierte Hyperpolarisation

Angewandte Chemie, EarlyView.
Die schnelle Parawasserstoff‐Hyperpolarisation in Kombination mit einfacher Verdünnung ermöglicht die Zufuhr von hyperpolarisiertem, biokompatiblen Pyruvats zu immobilisierten lebenden Zellen innerhalb von ≈1 min. Wiederholte Substratinjektionen offenbaren frequenzabhängige metabolische Dynamiken und eröffnen damit eine neue zeitliche Dimension für ...
Philipp R. Groß, Stefan Petersen, Zirun Wang, Behnam Shamshiri, Henri de Maissin, Sebastian Lucas, Oliver Gorka, Lisa Heß, Irene Marco‐Rius, Lluís Mangas‐Florencio, André F. Martins, Philipp Boehm‐Sturm, Maxim Zaitsev, Robert Zeiser, Jan‐Bernd Hövener, Thomas Reinheckel, Olaf Groß, Andreas B. Schmidt   +17 more
wiley   +1 more source

Short-chain fatty acids in ulcerative colitis: integrating metabolic fate, dynamic biomarkers, and precision delivery

Frontiers in Nutrition
Ulcerative colitis (UC) is characterized by gut dysbiosis and impaired mucosal metabolism, positioning short-chain fatty acids (SCFAs) as pivotal mediators. This review moves beyond general mechanisms, offering an in-depth analysis of SCFA metabolic fate,
Ziyi Ying, Mengjia Tian, Xuan Huang, Guoqing Ping, Chaohong Jiang   +4 more
doaj   +1 more source

Minute‐Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen‐Based Hyperpolarization

Angewandte Chemie International Edition, EarlyView.
Rapid parahydrogen hyperpolarization combined with simple dilution enables biocompatible delivery of hyperpolarized pyruvate to immobilized living cells within ≈1 min. Repeated substrate injections reveal frequency‐dependent metabolic dynamics, introducing a new temporal dimension for hyperpolarized NMR studies of cellular metabolism and enabling rapid
Philipp R. Groß, Stefan Petersen, Zirun Wang, Behnam Shamshiri, Henri de Maissin, Sebastian Lucas, Oliver Gorka, Lisa Heß, Irene Marco‐Rius, Lluís Mangas‐Florencio, André F. Martins, Philipp Boehm‐Sturm, Maxim Zaitsev, Robert Zeiser, Jan‐Bernd Hövener, Thomas Reinheckel, Olaf Groß, Andreas B. Schmidt   +17 more
wiley   +1 more source

Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy

Neurobiology of Disease, 2012
Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes.
Fredrik Lauritzen, Edgar L. Perez, Eric R. Melillo, Jung-Min Roh, Hitten P. Zaveri, Tih-Shih W. Lee, Yue Wang, Linda H. Bergersen, Tore Eid   +8 more
doaj   +1 more source

Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes [PDF]

Diabetes, 2006
We hypothesized that increased capacity for brain utilization of nonglucose substrates (monocarboxylic acids [MCAs]) by upregulation of the MCA transporters may contribute metabolic substrates during hypoglycemia. To test this hypothesis, we assessed brain acetate metabolism in five well-controlled type 1 diabetic subjects and six nondiabetic control ...
Graeme F, Mason, Kitt F, Petersen, Vincent, Lebon, Douglas L, Rothman, Gerald I, Shulman   +4 more
openaire   +2 more sources

Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea.
Baptiste Ganachaud, María José Mendoza‐León, Justine Marchix, Alonso Fernandez Tello, Catherine Le Berre Scoul, Ma Cecilia Opazo, Michel Neunlist, Claudia A. Riedel, Martial Caillaud, Hélène Boudin   +9 more
wiley   +1 more source