Results 51 to 60 of about 113,465,300 (217)

Structural and functional study of the nitrate transporter, NrtA [PDF]

, 2013
Membrane proteins play a crucial role in most cellular processes. Transporter integral proteins carry a whole variety of solute molecules across biological membranes.
Da Silva, Ingrid Rodrigues Nunes
core   +2 more sources

The effect of pre-exercise alkalosis on lactate/pH regulation and mitochondrial respiration following sprint-interval exercise in humans

Frontiers in Physiology, 2023
Purpose: The purpose of this study was to evaluate the effect of pre-exercise alkalosis, induced via ingestion of sodium bicarbonate, on changes to lactate/pH regulatory proteins and mitochondrial function induced by a sprint-interval exercise session in
Claire Thomas, Claire Thomas, Rémi Delfour‐Peyrethon, Rémi Delfour‐Peyrethon, Karen Lambert, Cesare Granata, Cesare Granata, Cesare Granata, Cesare Granata, Thomas Hobbs, Christine Hanon, Christine Hanon, David J. Bishop   +12 more
doaj   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk

Nature Communications
Acute myeloid leukemia is an aggressive hematological malignancy frequently complicated by coagulation disorders, including thrombosis and hemorrhage, which contribute to poor outcomes.
Qin Bai, Yu-Xiang Qiu, Huan Zeng, Li-Hua Yao, Fang-Min Zhong, Yan-Mei Xu, Jing Zhang, Bo Huang, Jing Liu, Hang Shi, Xuan Hou, Zi-Hao Wang, Ke-Yu Deng, Xiao-Zhong Wang   +13 more
doaj   +1 more source

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates

Asian Journal of Pharmaceutical Sciences, 2019
Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun, Dongyang Zhao, Gang Wang, Qikun Jiang, Mengran Guo, Qiming Kan, Zhonggui He, Jin Sun   +7 more
doaj   +1 more source

“Aerobic glycolytic imaging” of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging

NeuroImage: Clinical, 2021
Purpose: To quantify abnormal metabolism of diffuse gliomas using “aerobic glycolytic imaging” and investigate its biological correlation. Methods: All subjects underwent a pH-weighted amine chemical exchange saturation transfer spin-and-gradient-echo ...
Akifumi Hagiwara, Jingwen Yao, Catalina Raymond, Nicholas S. Cho, Richard Everson, Kunal Patel, Danielle H. Morrow, Brandon R. Desousa, Sergey Mareninov, Saewon Chun, David A. Nathanson, William H. Yong, Gafita Andrei, Ajit S. Divakaruni, Noriko Salamon, Whitney B. Pope, Phioanh L. Nghiemphu, Linda M. Liau, Timothy F. Cloughesy, Benjamin M. Ellingson   +19 more
doaj   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Monocarboxylate Transporter 8 Deficiency [PDF]

, 2021
Genetic defects in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in MCT8 deficiency. This disorder is characterized by a combination of severe intellectual and motor disability, caused by decreased cerebral thyroid hormone ...
N. (Nilhan) Gunhanlar, F.S. (Ferdy) van Geest, Visser, W. Edward, W. Edward Visser, W.E. (Edward) Visser, Ferdy S. van Geest, Stefan Groeneweg, S. (Stefan) Groeneweg, van Geest, Ferdy S., Gunhanlar, Nilhan, Groeneweg, Stefan, Nilhan Gunhanlar   +11 more
core   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

A trap transporter for pyruvate and other monocarboxylate 2-oxoacids in the cyanobacterium Anabaena sp. strain PCC 7120 [PDF]

, 2010
In the cyanobacterium Anabaena sp. strain PCC 7120, open reading frames (ORFs) alr3026, alr3027, and all3028 encode a tripartite ATP-independent periplasmic transporter (TRAP-T).
Enrique Flores, Antonia Herrero, Pernil, Rafael, Flores García, Enrique, Rafael Pernil, Herrero Moreno, Antonia   +5 more
core   +1 more source