Results 61 to 70 of about 113,465,300 (217)

The expression pattern of butyric acid transporter in the large intestine with growth and development of suckling lambs [PDF]

Animal Bioscience
Objective The objective of this research was to explore the changes of morphological parameters, short chain fatty acid contents and butyric acid transporter expression levels in the large intestine with growth and development of sucking lambs. Methods A
Jian Ma, Tao Li, Lu Lin, Chunmei Du, Chen Wei, Fuquan Yin, Xuemei Sun, Gang Lyu, Shangquan Gan   +8 more
doaj   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Short-chain fatty acids in ulcerative colitis: integrating metabolic fate, dynamic biomarkers, and precision delivery

Frontiers in Nutrition
Ulcerative colitis (UC) is characterized by gut dysbiosis and impaired mucosal metabolism, positioning short-chain fatty acids (SCFAs) as pivotal mediators. This review moves beyond general mechanisms, offering an in-depth analysis of SCFA metabolic fate,
Ziyi Ying, Mengjia Tian, Xuan Huang, Guoqing Ping, Chaohong Jiang   +4 more
doaj   +1 more source

The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease

Frontiers in Immunology, 2023
Kawasaki disease (KD), an acute febrile systemic vasculitis in children, has become the leading cause of acquired heart disease in developed countries. Recently, the altered gut microbiota was found in KD patients during the acute phase.
Fangyan Wang, Fangyan Wang, Fanyu Qian, Fanyu Qian, Qihao Zhang, Qihao Zhang, Jian Zhao, Jian Zhao, Jianke Cen, Jianke Cen, Jiamin Zhang, Jiamin Zhang, Jinhui Zhou, Jinhui Zhou, Ming Luo, Ming Luo, Chang Jia, Chang Jia, Xing Rong, Xing Rong, Maoping Chu, Maoping Chu, Maoping Chu   +22 more
doaj   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Hyperoxia induces glucose metabolism reprogramming and intracellular acidification by suppressing MYC/MCT1 axis in lung cancer

Redox Biology, 2023
The perils and promises of inspiratory hyperoxia (IH) in oncology are still controversial, especially for patients with lung cancer. Increasing evidence shows that hyperoxia exposure is relevant to the tumor microenvironment.
Xiucheng Liu, Hao Qin, Li Zhang, Caili Jia, Zhixiang Chao, Xichun Qin, Hao Zhang, Chang Chen   +7 more
doaj   +1 more source

Batch‐to‐Batch Optimization of pH Shifts in CHO Bioreactor Operations

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Culture pH is an important operating parameter in CHO cell cultures producing mAb since it directly affects growth and specific productivity. Mathematical models can be used to optimize the magnitude and timing of pH shifts provided that they are robust to model errors.
Ali Ghodba, Zahra Negahban, Anne Richelle, Chris McCready, Valerie Ward, Luis Ricardez‐Sandoval, Hector Budman   +6 more
wiley   +1 more source

Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy

Neurobiology of Disease, 2012
Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes.
Fredrik Lauritzen, Edgar L. Perez, Eric R. Melillo, Jung-Min Roh, Hitten P. Zaveri, Tih-Shih W. Lee, Yue Wang, Linda H. Bergersen, Tore Eid   +8 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Crizotinib: A Novel Strategy to Reverse Immunosuppression in Melanoma by Targeting Lactate Transport

MedComm
Lactate is a vital metabolite in cancer, significantly impacting tumor progression, metastasis, and overall survival. The CD147–monocarboxylate transporter 1 (MCT1) complex, a major lactate transporter, has emerged as a promising therapeutic target ...
Zhe Zhou, Xu Zhang, Susi Zhu, Waner Liu, Yeye Guo, Siyu Xiong, Cong Peng, Xiang Chen   +7 more
doaj   +1 more source