Results 81 to 90 of about 113,465,300 (217)

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

The expression of monocarboxylate transporters in thyroid carcinoma can be associated with the morphological features of BRAFV600E mutation [PDF]

, 2016
BRAFV600E mutation, usually performed by DNA techniques, is one of the most common diagnostic markers in papillary thyroid carcinoma. Few papers have demonstrated that plump cells (eosinophilic cytoplasms and papillary thyroid carcinoma nuclei) and ...
Fadda G., Larocca L. M., Larocca, Luigi Maria, Baltazar, Fátima, Lombardi C. P., Fadda, Guido, Rossi E., Capodimonti S., Pontecorvi, Alfredo, Pontecorvi A., Capodimonti, Sara, Granja, Sara Costa, Bizzarro, Tommaso, Martini M., Lombardi, Celestino Pio, Luca, Emilia, et. al., Martini, Maurizio, Rossi, Esther Diana, Lombardi, C. P., Rossi, E. D., Larocca, L. M., Schmitt, F., Fadda, G., Capodimonti, S., Luca, E., Bizzarro, T., Baltazar, F., Granja, S., Pontecorvi, A., Martini, M.   +30 more
core   +1 more source

The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors

Frontiers in Endocrinology, 2019
Testicular Germ Cell Tumors (TGCTs) are a rare group of neoplasms and the most common solid malignancy arising in young male adults. Despite the good response of these tumors to platinum-based chemotherapy, some patients are refractory to treatment and ...
Murilo Bonatelli, Eduardo C. A. Silva, Flavio M. Cárcano, Flavio M. Cárcano, Maurício G. Zaia, Luiz F. Lopes, Cristovam Scapulatempo-Neto, Cristovam Scapulatempo-Neto, Céline Pinheiro, Céline Pinheiro   +9 more
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

, 2015
Novel substituted pteridine-derived inhibitors of monocarboxylate transporter 1 (MCT1), an emerging target for cancer therapy, are reported. The activity of these compounds as inhibitors of lactate transport was confirmed using a 14C-lactate transport ...
Hui Wang (30400), Joanne R. Doherty (1334337), William R. Roush (1334334), Chunying Yang (645887), John L. Cleveland (200680), Thomas D. Bannister (713175)   +5 more
core   +1 more source

Metabolic Compartmentalization in Colorectal Cancer Hepatic Metastases and Correlation with Tumor Aggressiveness

Gastrointestinal Disorders
At the time of colorectal cancer (CRC) diagnosis, approximately 25% of patients present with liver metastases, and 70% develop them during follow-up. This is the primary cause of therapeutic failure and most associated deaths, making it imperative to ...
Nuno Castro, Mariana Fernandes, Ana Pereira, Mariana Costa, Nuno Machado, Cláudio Branco, Carlos Veiga, Adhemar Longatto-Filho, Sandra F. Martins   +8 more
doaj   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source

Testosterone Mediated Renal Monocarboxylate Transporter Expression

, 2023
The kidney is a major route of elimination with renal excretion a function of glomerular filtration, tubular secretion and tubular reabsorption. The extent of active tubular reabsorption and secretion of substrates is governed by transporters.
Wei, Hao, Lee, Annie, Felmlee, Melanie, Matthews, Tori, Zhang, Qing   +4 more
core   +1 more source

Chronic glucocorticoid exposure disrupts lactate homeostasis and hippocampal neurogenesis by reducing cerebrovascular monocarboxylate transporter 1, leading to behavioral abnormalities in mice

Journal of Pharmacological Sciences
Prolonged glucocorticoid elevation is strongly associated with brain dysfunction and the pathogenesis of stress-related disorders, including several psychiatric disorders.
Ayami Kita-Shirakura, Kaede Ishihara, Nagisa Kimura, Momoka Tanida, Ryota Araki, Takeshi Yabe   +5 more
doaj   +1 more source