Results 41 to 50 of about 113,465,300 (217)

Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

Clinical and Translational Science, 2021
This study determined absolute transporter protein abundances in isolated microvessels of human noncancerous cerebral cortex as well as brain metastases of patients with lung and breast cancer, using a validated targeted proteomics approach.
Xun Bao, Jianmei Wu, Jun Jiang, An‐Chi Tien, Nader Sanai, Jing Li   +5 more
doaj   +1 more source

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Cell Reports, 2021
Summary: Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate and pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1).
Thomas Philips, Yevgeniya A. Mironova, Yan Jouroukhin, Jeannie Chew, Svetlana Vidensky, Mohamed H. Farah, Mikhail V. Pletnikov, Dwight E. Bergles, Brett M. Morrison, Jeffrey D. Rothstein   +9 more
doaj   +1 more source

Monocarboxylate Transporters 1 and 4 and Prognosis in Small Bowel Neuroendocrine Tumors

Cancers, 2022
Monocarboxylate transporters (MCTs) are cell membrane proteins transporting lactate, pyruvate, and ketone bodies across the plasma membrane. The prognostic role of MCTs in neuroendocrine tumors is unknown. We aimed to analyze MCT1 and MCT4 expression in small bowel neuroendocrine tumors (SB-NETs).
Niko Hiltunen, Jukka Rintala, Juha P. Väyrynen, Jan Böhm, Tuomo J. Karttunen, Heikki Huhta, Olli Helminen   +6 more
openaire   +3 more sources

Exercise-induced hyperinsulinism: genetic basis and clinical management

中国当代儿科杂志
Exercise-induced hyperinsulinism, also known as monocarboxylate transporter 1 hyperinsulinemia, is a rare subtype of congenital hyperinsulinism caused by gain-of-function variants in the SLC16A1 gene, which encodes monocarboxylate transporter 1.
ZHANG Qi-Ting, HOU Ling
doaj   +1 more source

Expression of Monocarboxylate Transporter 1 (MCT1) in the Dog Intestine

Journal of Veterinary Medical Science, 2007
In this study, the expression and distribution of monocarboxyolate transporter 1 (MCT1) along the intestines (duodenum, jejunum, ileum, cecum, colon and rectum) of dogs were investigated at both the mRNA and protein levels. The expression of MCT1 protein and its distribution were confirmed by Western blotting and immunohistochemical staining using the ...
SHIMOYAMA, Yumiko, KIRAT, Doaa, AKIHARA, Yuko, KAWASAKO, Kazufumi, KOMINE, Misa, HIRAYAMA, Kazuko, MATSUDA, Kazuya, OKAMOTO, Minoru, IWANO, Hidetomo, KATO, Seiyu, TANIYAMA, Hiroyuki   +10 more
openaire   +3 more sources

Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status

Antioxidants
Beneficial effects of the microbiota-derived metabolite butyrate at the colonic level are well established, particularly through its relevance in colorectal cancer (CRC) and inflammatory bowel disease (IBD), two major intestinal pathologies.
Fátima Martel
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Monocarboxylate Transporters 1 and 4 Are Associated with CD147 in Cervical Carcinoma

Disease Markers, 2009
Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH ...
Pinheiro, Céline, Baltazar, Fátima, Longatto Filho, Adhemar, Pereira, Sónia Maria Miranda, Etlinger, Daniela, Moreira, Marise A. R., Jubé, L. F., Queiroz, Geraldo Silva, Schmitt, Fernando C.   +8 more
openaire   +3 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source