Results 21 to 30 of about 13,855 (152)

IMMUNOHISTOCHEMICAL EXPRESSION OF MONOCARBOXYLATE TRANSPORTER 1&4 IN TANYCYTE–LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM

The Iraqi Journal of Medical Sciences, 2019
Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider Jawad, Muthanna Al-Kaabi, Anam Al-Salihi   +2 more
doaj   +1 more source

Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status

Antioxidants
Beneficial effects of the microbiota-derived metabolite butyrate at the colonic level are well established, particularly through its relevance in colorectal cancer (CRC) and inflammatory bowel disease (IBD), two major intestinal pathologies.
Fátima Martel
doaj   +1 more source

The role of the genetic factor of lactate transport in endurance sports

Здоров’я, спорт, реабілітація
Background and purpose With the growth of sports results, more and more attention is paid to identifying the role of genetic factors in various metabolic processes. One of these factors is the protein responsible for the transport of lactate.
Rafia Fathi, Abdul Al Majidi, Khamael Nhab, Rehab Ramadhan, Ratko Pavlović   +4 more
doaj   +3 more sources

Generation of two human induced pluripotent stem cell lines from Allan-Herndon-Dudley syndrome (AHDS) patients with SLC16A2:G401R or SLC16A2: H192R mutation

Stem Cell Research
Allan-Herndon-Dudley syndrome (AHDS) is an X-linked disorder characterized by profound psychomotor impairment. It is caused by mutations in the SLC16A2 gene, which encodes monocarboxylate transporter 8 (MCT8), a crucial thyroid hormone transporter.
Katarzyna A. Ludwik, Judit Küchler, David Sebinger, Robert Opitz, Peter Kühnen, Harald Stachelscheid   +5 more
doaj   +1 more source

“Aerobic glycolytic imaging” of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging

NeuroImage: Clinical, 2021
Purpose: To quantify abnormal metabolism of diffuse gliomas using “aerobic glycolytic imaging” and investigate its biological correlation. Methods: All subjects underwent a pH-weighted amine chemical exchange saturation transfer spin-and-gradient-echo ...
Akifumi Hagiwara, Jingwen Yao, Catalina Raymond, Nicholas S. Cho, Richard Everson, Kunal Patel, Danielle H. Morrow, Brandon R. Desousa, Sergey Mareninov, Saewon Chun, David A. Nathanson, William H. Yong, Gafita Andrei, Ajit S. Divakaruni, Noriko Salamon, Whitney B. Pope, Phioanh L. Nghiemphu, Linda M. Liau, Timothy F. Cloughesy, Benjamin M. Ellingson   +19 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells

Cancer Cell International, 2019
Background The Warburg effect demonstrates the importance of glycolysis in the development of primary and metastatic cancers. We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential transporters of lactate, in renal ...
Chen Guo, Tao Huang, Qing-Hai Wang, Hong Li, Aashish Khanal, En-Hao Kang, Wei Zhang, Hai-Tao Niu, Zhen Dong, Yan-Wei Cao   +9 more
doaj   +1 more source

Monocarboxylate Transporter 8 Deficiency: From Pathophysiological Understanding to Therapy Development

Frontiers in Endocrinology, 2021
Genetic defects in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in MCT8 deficiency. This disorder is characterized by a combination of severe intellectual and motor disability, caused by decreased cerebral thyroid hormone ...
Ferdy S. van Geest, Nilhan Gunhanlar, Stefan Groeneweg, W. Edward Visser   +3 more
doaj   +1 more source