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The monocarboxylate transporter family—Role and regulation [PDF]
IUBMB Life, 2011 AbstractMonocarboxylate transporter (MCT) isoforms 1–4 catalyze the proton‐linked transport of monocarboxylates such as L‐lactate across the plasma membrane, whereas MCT8 and MCT10 are thyroid hormone and aromatic amino acid transporters, respectively.
Halestrap, AP, Wilson, MC
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Journal of Biomedical Science, 2022 Background Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic drug and a histone deacetylase ...
Asmita Gyawali +5 more
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Monocarboxylate transporters: past, present, and future.
Histology and histopathology, 2008 We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hormones. The family is denoted Solute
Merezhinskaya, Natalya +1 more
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Lactate transport in red blood cells by monocarboxylate transporters [PDF]
Equine Veterinary Journal, 2002 Summary The lactate transport activity of red blood cells (RBC) varies widely among different species; in equine RBC, the activity of the main lactate carrier, H + ‐monocarboxylate co‐transporter (MCT), is distributed bimodally. The influence of lactate transport activity is
N M, Koho, L K, Väihkönen, A R, Pösö
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Monocarboxylate Transporter 1 (MCT1) in Liver Pathology [PDF]
International Journal of Molecular Sciences, 2020 Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function. The study was aimed to quantify SLC16A1 mRNA (qRT-PCR) and MCT1 protein abundance (liquid chromatography–
Marek Droździk +8 more
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The Iraqi Journal of Medical Sciences, 2019 Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider F. Jawad +2 more
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Nature Communications, 2017 Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 ...
Chun-Kai Huang +8 more
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Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
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Exercise-induced hyperinsulinism: genetic basis and clinical management
中国当代儿科杂志Exercise-induced hyperinsulinism, also known as monocarboxylate transporter 1 hyperinsulinemia, is a rare subtype of congenital hyperinsulinism caused by gain-of-function variants in the SLC16A1 gene, which encodes monocarboxylate transporter 1.
ZHANG Qi-Ting, HOU Ling
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Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out
Stem Cell Research, 2023 The X-linked Allan-Herndon-Dudley syndrome (AHDS) is characterized by severely impaired psychomotor development and is caused by mutations in the SLC16A2 gene encoding the thyroid hormone transporter MCT8 (monocarboxylate transporter 8).
Katarzyna Anna Ludwik +7 more
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