Monocarboxylate transporters in cancer [PDF]
Molecular Metabolism, 2020 Background: Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer cells may use 4 main fuels that are shuttled in 5 different metabolic pathways ...
Valéry L. Payen +4 more
doaj +7 more sources
Distribution of Monocarboxylate Transporters in Brain and Choroid Plexus Epithelium [PDF]
Pharmaceutics, 2023 The choroid plexus (CP) plays central roles in regulating the microenvironment of the central nervous system by secreting the majority of cerebrospinal fluid (CSF) and controlling its composition. A monolayer of epithelial cells of CP plays a significant
Masaki Ueno, Yoichi Chiba, Ken Yanase
exaly +5 more sources
Molecular mechanism of thyroxine transport by monocarboxylate transporters [PDF]
Nature CommunicationsThyroid hormones (the common name for prohormone thyroxine and the bioactive form triiodothyronine) control major developmental and metabolic processes.
Matteo Tassinari +10 more
doaj +6 more sources
The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells [PDF]
Metabolites, 2021 There is a growing body of evidence that metabolic reprogramming contributes to the acquisition and maintenance of robustness associated with malignancy.
Go J. Yoshida
doaj +3 more sources
Monocarboxylate Transporters: Role and Regulation in Corneal Diabetes [PDF]
Analytical Cellular Pathology, 2022 Diabetes mellitus (DM) is a group of metabolic diseases that is known to cause structural and functional ocular complications. In the human cornea, DM-related complications affect the epithelium, stroma, and nerves.
Pawan Shrestha +5 more
doaj +4 more sources
Importance of lactate dehydrogenase (LDH) and monocarboxylate transporters (MCTs) in cancer cells [PDF]
Health Science Reports, 2023 Background In most regions, cancer ranks the second most frequent cause of death following cardiovascular disorders. Aim In this article, we review the various aspects of glycolysis with a focus on types of MCTs and the importance of lactate in cancer ...
Hamed Hatami +3 more
doaj +2 more sources
Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications [PDF]
Frontiers in Cell and Developmental Biology, 2022 The Warburg effect is known as the hyperactive glycolysis that provides the energy needed for rapid growth and proliferation in most tumor cells even under the condition of sufficient oxygen.
Qixin Duan +6 more
doaj +2 more sources
Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10 [PDF]
Biomedicines, 2021 The monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are important for thyroid hormone (TH) uptake and signaling. Reduced TH activity is associated with impaired development, weight gain and discomfort.
Theresa Porst +9 more
doaj +2 more sources
Role of monocarboxylate transporters in the diagnosis, progression, prognosis, and treatment of prostate cancer [PDF]
Urology Research and Practice, 2020 Prostate cancer (PCa) is a disease with high morbidity and mortality rates, which requires finding new lines of approach. The significant advances in and interest of molecular biology in this condition have led to the discovery of elements profiled as an
Javier Eduardo Rengifo Rodriguez +1 more
doaj +2 more sources
Short chain fatty acids and monocarboxylate transporters in irritable bowel syndrome [PDF]
The Turkish Journal of Gastroenterology, 2020 Background/Aims: Gut microbiota ferments indigestible food that rests in the colon to produce short-chain fatty acids (SCFAs) acetate, propionate, and butyrate.
Ernst Fredericks +2 more
doaj +2 more sources