The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival [PDF]
eLifeThe apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown.
Hui Dong +12 more
doaj +4 more sources
Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review [PDF]
Acta Veterinaria Scandinavica, 2002 Lactate is known as the end product of anaerobic glycolysis, a pathway that is of key importance during high intensity exercise. Instead of being a waste product lactate is now regarded as a valuable substrate that significantly contributes to the ...
Pösö AR
doaj +2 more sources
Cooperative transport mechanism of human monocarboxylate transporter 2 [PDF]
Nature Communications, 2020 Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells.
Bo Zhang +14 more
doaj +3 more sources
Monocarboxylate transporters in the brain and in cancer. [PDF]
Biochim Biophys Acta, 2016 Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires interaction with chaperon protein such as basigin/CD147 and ...
Pérez-Escuredo J +6 more
europepmc +6 more sources
Structure and function of a monocarboxylate transporter homolog specific for L-lactate [PDF]
Molecular & Cellular Oncology, 2019 Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor.
Patrick D. Bosshart +3 more
doaj +3 more sources
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy [PDF]
Cell Communication and SignalingBackground Disruption of energy support to peripheral nerves leads to dysfunction and degeneration of both neuronal axons and Schwann cells (SCs).
Tae Woo Kim +10 more
doaj +2 more sources
Candidate genes for performance in horses, including monocarboxylate transporters [PDF]
Pesquisa Veterinária Brasileira, 2017 : Some horse breeds are highly selected for athletic activities. The athletic potential of each animal can be measured by its performance in sports. High athletic performance depends on the animal capacity to produce energy through aerobic and anaerobic ...
Inaê Cristina Regatieri +3 more
doaj +3 more sources
A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters [PDF]
eLifeTransporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal physiological ...
Pattama Wiriyasermkul +13 more
doaj +2 more sources
Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status
AntioxidantsBeneficial effects of the microbiota-derived metabolite butyrate at the colonic level are well established, particularly through its relevance in colorectal cancer (CRC) and inflammatory bowel disease (IBD), two major intestinal pathologies.
Fátima Martel
doaj +2 more sources
Isolation of Functional Human MCT Transporters in Saccharomyces cerevisiae
CellsHuman monocarboxylate transporters (hMCTs) belong to the solute carrier 16 (SLC16) family of proteins and are responsible for the bi-directional transport of various metabolites, including monocarboxylates, hormones, and aromatic amino acids.
Hajira Ahmed Hotiana +4 more
doaj +3 more sources