Results 21 to 30 of about 97,734 (211)

Tissue-specific expression of monocarboxylate transporters during fasting in mice. [PDF]

PLoS ONE, 2014
Monocarboxylates such as pyruvate, lactate and ketone bodies are crucial for energy supply of all tissues, especially during energy restriction. The transport of monocarboxylates across the plasma membrane of cells is mediated by monocarboxylate ...
Alexandra Schutkowski, Nicole Wege, Gabriele I Stangl, Bettina König   +3 more
doaj   +2 more sources

Intrinsic Asymmetry in Weak Acid Transmembrane Transporters

Biomolecules
Transmembrane facilitation of substrates by channels and secondary active transporters results in a defined steady-state concentration ratio across the membrane.
Emmi Jaeger, Sebastian Buss, Eric Beitz
doaj   +2 more sources

Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters [PDF]

Scientific Reports, 2017
Epilepsy is a chronic neurological disorder that affects approximately 50 million people worldwide. Ketogenic diet (KD) can be a very effective treatment for intractable epilepsy. Potential mechanisms of action for KD have been proposed, including the re-
Linda S. Forero-Quintero, Joachim W. Deitmer, Holger M. Becker   +2 more
doaj   +2 more sources

Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer. [PDF]

Cancers (Basel), 2021
Background: Monocarboxylate transporters (MCTs) appear to play an important role in tumor development and aggressiveness. The present study aimed to evaluate associations between cytoplasmic MCT1, MCT4, and mitochondrial cytochrome c oxidase (MTCO1 ...
Eskuri M, Kemi N, Kauppila JH.
europepmc   +2 more sources

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes. [PDF]

Nat Metab
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation in mice.
Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, Smith A, Ordonez M, Laznik-Bogoslavski D, Rothstein JD, Mills EL, Chouchani ET.   +11 more
europepmc   +2 more sources

Harnessing Lactate Metabolism for Radiosensitization

Frontiers in Oncology, 2021
Cancer cells rewire their metabolism to promote cell proliferation, invasion, and metastasis. Alterations in the lactate pathway have been characterized in diverse cancers, correlate with outcomes, and lead to many downstream effects, including ...
Kevin X. Liu, Emily Everdell, Sharmistha Pal, Daphne A. Haas-Kogan, Michael G. Milligan   +4 more
doaj   +1 more source

The clinicopathological significance of monocarboxylate transporters in testicular germ cell tumors. [PDF]

Oncotarget, 2018
Metabolic reprogramming is one of the hallmarks of cancer. The hyperglycolytic phenotype is often associated with the overexpression of metabolism-associated proteins, such as monocarboxylate transporters (MCTs).
Silva ECA, Cárcano FM, Bonatelli M, Zaia MG, Morais-Santos F, Baltazar F, Lopes LF, Scapulatempo-Neto C, Pinheiro C.   +8 more
europepmc   +2 more sources

Effect of Sex and Cross-Sex Hormone Treatment on Renal Monocarboxylate-Transporter Expression in Rats

Pharmaceutics, 2023
Proton- and sodium-dependent monocarboxylate transporters (MCTs/SMCTs) are determinants of renal clearance through the renal reabsorption of monocarboxylate substrates.
Hao Wei, Annie Lee, Qing Zhang, Melanie A. Felmlee   +3 more
doaj   +1 more source

Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice [PDF]

, 2013
Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay.
Laurence S Loubière, Visser, Theo, Whitley G.S., Elisavet Vasilopoulou (420760), Loubière Laurence S., Darras, V.M. (Veerle), Loubière L.S., Darras, VM, Kilby, MD, Trajkovic-Arsic, M. (Marija), Christopher J McCabe, Guy S Whitley, Heike Heuer (420762), Heuer, H, Marija Trajkovic-Arsic, Guy S. Whitley (420764), Visser T.J., McCabe, Christopher, Gendie E. Lash (420763), Visser Theo J., Theo J. Visser (280338), Marija Trajkovic-Arsic (155746), Kilby, Mark, Franklyn, J.A. (Jayne), Mark D. Kilby (420766), Loubière, LS, Trajkovic-Arsic, M, Lash G.E., Loubière, L.S. (Laurence), Whitley Guy S., Darras, Veerle, Jayne A Franklyn, Christopher J. McCabe (420765), Loubière, Laurence, Heuer Heike, Darras V.M., Jayne A. Franklyn (236549), Whitley, Guy, Lash, G.E. (Gendie), Franklyn, Jayne, Gendie E Lash, Whitley, GS, Vasilopoulou, E, McCabe, CJ, Franklyn Jayne A., Franklyn J.A., Shiao Y Chan, Visser, TJ, Chan, SY, Veerle M Darras, Chan, Shiao, Elisavet Vasilopoulou, Heuer H., Vasilopoulou, Elisavet, Vasilopoulou Elisavet, Heuer, Heike, Lash Gendie E., Visser, T.J. (Theo), Heike Heuer, Shiao Y. Chan (420767), McCabe, C.J. (Christopher), Lash, GE, Chan S.Y., Vasilopoulou, E. (Elisavet), Kilby, M.D. (Mark), Trajkovic-Arsic M., Veerle M. Darras (104459), Heuer, H. (Heike), Chan, S.Y. (Shiao), Laurence S. Loubière (420761), McCabe Christopher J., Whitley, G.S. (Guy), Mark D Kilby, Darras Veerle M., McCabe C.J., Trajkovic-Arsic, Marija, Kilby Mark D., Franklyn, JA, Trajkovic-Arsic Marija, Chan Shiao Y., Lash, Gendie, Vasilopoulou E., Theo J Visser, Kilby M.D.   +83 more
core   +1 more source

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

Frontiers in Neuroscience, 2015
The transcriptome of embryonic and adult rat lateral ventricular choroid plexus, using a combination of RNA-Sequencing and microarray data, was analysed by functional groups of influx transporters, particularly solute carrier (SLC) transporters.
Norman Ruthven Saunders
doaj   +1 more source