Results 41 to 50 of about 97,734 (211)

Monocarboxylate transporters: past, present, and future.

Histology and histopathology, 2008
We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hormones. The family is denoted Solute
Merezhinskaya, Natalya, Fishbein, William N.   +1 more
openaire   +3 more sources

Expression, purification and crystallization of an SLC16 monocarboxylate transporter family homologue specific for l-lactate. [PDF]

, 2020
l-lactate plays an important role as metabolite and signaling molecule in eukaryotes and bacteria. Monocarboxylate transporters (MCTs) of the SLC16 solute carrier family are responsible for the transport of l-lactate across eukaryotic and bacterial cell ...
Hirschi, Stephan, Bonetti, Sara, Bosshart, Patrick D., Bosshart PD, Hirschi S, Bonetti S   +5 more
core   +4 more sources

Lactate transport in red blood cells by monocarboxylate transporters [PDF]

Equine Veterinary Journal, 2002
Summary The lactate transport activity of red blood cells (RBC) varies widely among different species; in equine RBC, the activity of the main lactate carrier, H + ‐monocarboxylate co‐transporter (MCT), is distributed bimodally. The influence of lactate transport activity is
N M, Koho, L K, Väihkönen, A R, Pösö
openaire   +2 more sources

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology [PDF]

International Journal of Molecular Sciences, 2020
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function. The study was aimed to quantify SLC16A1 mRNA (qRT-PCR) and MCT1 protein abundance (liquid chromatography–
Marek Droździk, Sylwia Szeląg-Pieniek, Justyna Grzegółkowska, Joanna Łapczuk-Romańska, Mariola Post, Pawel Domagała, Janusz Miętkiewski, Stefan Oswald, Mateusz Kurzawski   +8 more
openaire   +2 more sources

Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression [PDF]

, 2010
Background: \ud \ud The aim of this study is to seek an association between markers of metastatic potential, drug resistance-related protein and monocarboxylate transporters in prostate cancer (CaP).\ud \ud Methods: \ud \ud We evaluated the expression ...
J Hao, Hao, J, Russell, P. J., Li, Y., W Xiao, W J Delprado, Beretov, J., P J Russell, Chen, H, Cozzi, P J, Xiao, W, Russell, P J, P J Cozzi, Xiao, W., Delprado, W. J., Y Li, Delprado, W J, Madigan, M. C., M C Madigan, Li, Y, J Beretov, Hao, J., H Chen, Chen, H., Madigan, M C, Beretov, J, Cozzi, P. J.   +26 more
core   +1 more source

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

Cell Reports, 2019
Summary: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival ...
Kathrin Renner, Christina Bruss, Annette Schnell, Gudrun Koehl, Holger M. Becker, Matthias Fante, Ayse-Nur Menevse, Nathalie Kauer, Raquel Blazquez, Lisa Hacker, Sonja-Maria Decking, Toszka Bohn, Stephanie Faerber, Katja Evert, Lisa Aigle, Sabine Amslinger, Maria Landa, Oscar Krijgsman, Elisa A. Rozeman, Christina Brummer, Peter J. Siska, Katrin Singer, Stefanie Pektor, Matthias Miederer, Katrin Peter, Eva Gottfried, Wolfgang Herr, Ibtisam Marchiq, Jacques Pouyssegur, William R. Roush, SuFey Ong, Sarah Warren, Tobias Pukrop, Philipp Beckhove, Sven A. Lang, Tobias Bopp, Christian U. Blank, John L. Cleveland, Peter J. Oefner, Katja Dettmer, Mark Selby, Marina Kreutz   +41 more
doaj   +1 more source

Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

Nature Communications, 2019
The transport of L-lactate across plasma membranes is catalyzed by proton-driven monocarboxylate transporters (MCTs) of the SLC16 solute carrier family.
Patrick D. Bosshart, David Kalbermatter, Sara Bonetti, Dimitrios Fotiadis   +3 more
doaj   +1 more source

Targeting uptake transporters for cancer imaging and treatment

Acta Pharmaceutica Sinica B, 2020
Cancer cells reprogram their gene expression to promote growth, survival, proliferation, and invasiveness. The unique expression of certain uptake transporters in cancers and their innate function to concentrate small molecular substrates in cells make ...
Yuchen Zhang, Joanne Wang
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Thyroid hormone transporters: from molecules to patients [PDF]

, 2020
The studies in this doctoral thesis focus on thyroid hormone transporters, specifically monocarboxylate transporter (MCT) 8. The studies cover the whole spectrum from molecular studies on MCT8 structure and function to a phase II clinical trial with the ...
Groeneweg, Stefan, Groeneweg, S. (Stefan)   +1 more
core   +1 more source