Results 51 to 60 of about 97,734 (211)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Thyroid Hormone Transporters [PDF]

, 2020
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters
Peeters, R.P. (Robin), Visser, W.E. (Edward), Geest, F.S. (Ferdy) van, Heuer, H. (Heike), Groeneweg, S. (Stefan), Visser, Edward, Peeters, Robin, van Geest, Ferdy, Heuer, H, Groeneweg, Stefan   +9 more
core   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Monocarboxylate transporters (MCT) 1–4 in cancer and stromal cells as predictors of disease-specific survival in 335 NSCLC patients (univariate analyses; log-rank test).

, 2014
Monocarboxylate transporters (MCT) 1–4 in cancer and stromal cells as predictors of disease-specific survival in 335 NSCLC patients (univariate analyses; log-rank test).
Samer Al-Saad (186401), Roy M. Bremnes (186405), Marte Eilertsen (502637), Helge Stenvold (186390), Tom Donnem (186362), Ingvild Pettersen (630403), Khalid Al-Shibli (186396), Elin Richardsen (630404), Sigve Andersen (186387), Yury Kiselev (182528), Lill-Tove Busund (186409)   +10 more
core   +1 more source

Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as therapeutic targets [PDF]

, 2013
Background. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is
Costa, Paulo, Pires, Manuel Melo, Reis, Rui M., Bebiano, Gil, Cordeiro, Michelle, Baltazar, Fátima, Martinho, Olga, Gonçalves, Vera M., Pinheiro, Célia, Reis, R. M., Honavar, Mrinalini, Pires, Manuel M., Pinheiro, Céline, Palmeirim, Isabel, Palmeirim, I., Miranda-Goncalves, Vera   +15 more
core   +2 more sources

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Results of Cox regression analyses (backward stepwise model) for clinicopathological factors and monocarboxylate transporters (MCTs) (model 1) and metabolic co-expression variables (*model 2).

, 2014
Results of Cox regression analyses (backward stepwise model) for clinicopathological factors and monocarboxylate transporters (MCTs) (model 1) and metabolic co-expression variables (*model 2).
Samer Al-Saad (186401), Roy M. Bremnes (186405), Marte Eilertsen (502637), Helge Stenvold (186390), Tom Donnem (186362), Ingvild Pettersen (630403), Khalid Al-Shibli (186396), Elin Richardsen (630404), Sigve Andersen (186387), Yury Kiselev (182528), Lill-Tove Busund (186409)   +10 more
core   +1 more source

The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface. [PDF]

PLoS ONE, 2013
BackgroundThe neuroplastins np65 and np55 are two synapse-enriched immunoglobulin (Ig) superfamily adhesion molecules that contain 3 and 2 Ig domains respectively.
Marieangela C Wilson, Michaela Kraus, Hassan Marzban, Justyna R Sarna, Yisong Wang, Richard Hawkes, Andrew P Halestrap, Philip W Beesley   +7 more
doaj   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source