Results 61 to 70 of about 97,734 (211)

Monocarboxylate Transporter 8 Deficiency

Frontiers in Endocrinology, 2021
Genetic defects in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in MCT8 deficiency. This disorder is characterized by a combination of severe intellectual and motor disability, caused by decreased cerebral thyroid hormone signalling, and a chronic thyrotoxic state in peripheral tissues, caused by exposure to elevated ...
van Geest, Ferdy S., Gunhanlar, Nilhan, Groeneweg, Stefan, Visser, W. Edward   +3 more
openaire   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Monocarboxylate transporters: new molecular targets for colorectal carcinoma

, 2011
[Excerpt] Colorectal carcinoma (CRC) is the second leading cause of cancer-related death in industrialized countries1. 5-Fluorouracil (5-FU) is one of the most efficient chemotherapeutic agents in the treatment of CRC although resistance to 5-FU ...
Baltazar, Fátima, Pinheiro, Céline, Amorim, Ricardo, Pereira, Helena Paula Fernandes, Preto, Ana, Longatto Filho, Adhemar, Reis, R. L., Martins, Sandra   +7 more
core   +1 more source

Identification of Monocarboxylate Transporter 8 as a Specific Thyroid Hormone Transporter [PDF]

Journal of Biological Chemistry, 2003
Transport of thyroid hormone across the cell membrane is required for its action and metabolism. Recently, a T-type amino acid transporter was cloned which transports aromatic amino acids but not iodothyronines. This transporter belongs to the monocarboxylate transporter (MCT) family and is most homologous with MCT8 (SLC16A2).
Friesema, ECH, Ganguly, S, Abdalla, A, Manning Fox, JE, Halestrap, AP, Visser, TJ   +5 more
openaire   +3 more sources

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

The impact of tumour pH on cancer progression: strategies for clinical intervention

Exploration of Targeted Anti-tumor Therapy, 2020
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of ...
Carol Ward, James Meehan, Mark E Gray, Alan F Murray, David J Argyle, Ian H Kunkler, Simon P Langdon   +6 more
doaj   +1 more source

Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target

Exploration of Medicine, 2023
Abnormal energy metabolism is one of the ten hallmarks of tumors, and tumor cell metabolism provides energy and a suitable microenvironment for tumorigenesis and metastasis.
Weimei Xing, Xiaowei Li, Yuli Zhou, Mengsen Li, Mingyue Zhu   +4 more
doaj   +1 more source

Batch‐to‐Batch Optimization of pH Shifts in CHO Bioreactor Operations

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Culture pH is an important operating parameter in CHO cell cultures producing mAb since it directly affects growth and specific productivity. Mathematical models can be used to optimize the magnitude and timing of pH shifts provided that they are robust to model errors.
Ali Ghodba, Zahra Negahban, Anne Richelle, Chris McCready, Valerie Ward, Luis Ricardez‐Sandoval, Hector Budman   +6 more
wiley   +1 more source

Intravenous Bone Marrow Mononuclear Cells Transplantation in Aged Mice Increases Transcription of Glucose Transporter 1 and Na+/K+-ATPase at Hippocampus Followed by Restored Neurological Functions

Frontiers in Aging Neuroscience, 2020
We recently reported that intravenous bone marrow mononuclear cell (BM-MNC) transplantation in stroke improves neurological function through improvement of cerebral metabolism.
Yukiko Takeuchi, Yuka Okinaka, Yuko Ogawa, Akie Kikuchi-Taura, Yosky Kataoka, Yosky Kataoka, Sheraz Gul, Sheraz Gul, Carsten Claussen, Carsten Claussen, Johannes Boltze, Johannes Boltze, Akihiko Taguchi   +12 more
doaj   +1 more source

Monocarboxylate transporter and lactate metabolism

The Journal of Physical Fitness and Sports Medicine, 2012
For many years, lactate was considered as a metabolic waste product, and a cause of fatigue during exercise. However, lactate is now known as a carbohydrate fuel source, shuttled between cells and tissues. The movement of lactate across the plasma membrane is facilitated by a family of monocarboxylate transporters (MCTs).
Kitaoka, Yu, Hoshino, Daisuke, Hatta, Hideo   +2 more
openaire   +3 more sources