Results 31 to 40 of about 97,734 (211)

Hypoxia-inducible factor 1a (HIF 1a) and monocarboxylate transporter 1 (MCT 1) in papillary thyroid carcinoma; A study in Sulaimani City/Iraq

Advanced Medical Journal, 2023
Background and objectives: Papillary thyroid carcinoma is one of the most common cancers of human, monocarbox- ylate transporter 1 and hypoxia inducible factor 1 alpha expressions in many tumors have recently being targets for treatment, HIF-1a has been
Hadeel Adnan Yasseen, Ari Mohammed Abdullah   +1 more
doaj   +1 more source

Monocarboxylate transporter expression in mouse brain [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 1998
Although glucose is the major metabolic fuel needed for normal brain function, monocarboxylic acids, i.e., lactate, pyruvate, and ketone bodies, can also be utilized by the brain as alternative energy substrates. In most mammalian cells, these substrates are transported either into or out of the cell by a family of monocarboxylate transporters (MCTs),
E M, Koehler-Stec, I A, Simpson, S J, Vannucci, K T, Landschulz, W H, Landschulz   +4 more
openaire   +2 more sources

Volatile fatty acids production in ruminants and the role of monocarboxylate transporters: A review [PDF]

, 2013
Monocarboxylates commonly referred to as short-chain fatty acids (SCFAs) are metabolized to different extents by the epithelium of the gastrointestinal tract.
Abdullahi, A, Kobo, PI, Aluwong, T
core   +1 more source

Matrix Stiffness Modulates Metabolic Interaction between Human Stromal and Breast Cancer Cells to Stimulate Epithelial Motility

Metabolites, 2021
Breast tumors belong to the type of desmoplastic lesion in which a stiffer tissue structure is a determinant of breast cancer progression and constitutes a risk factor for breast cancer development.
Iván Ponce, Nelson Garrido, Nicolás Tobar, Francisco Melo, Patricio C. Smith, Jorge Martínez   +5 more
doaj   +1 more source

The expression of monocarboxylate transporters in thyroid carcinoma can be associated with the morphological features of BRAFV600E mutation [PDF]

, 2016
BRAFV600E mutation, usually performed by DNA techniques, is one of the most common diagnostic markers in papillary thyroid carcinoma. Few papers have demonstrated that plump cells (eosinophilic cytoplasms and papillary thyroid carcinoma nuclei) and ...
Fadda G., Larocca L. M., Larocca, Luigi Maria, Baltazar, Fátima, Lombardi C. P., Fadda, Guido, Rossi E., Capodimonti S., Pontecorvi, Alfredo, Pontecorvi A., Capodimonti, Sara, Granja, Sara Costa, Bizzarro, Tommaso, Martini M., Lombardi, Celestino Pio, Luca, Emilia, et. al., Martini, Maurizio, Rossi, Esther Diana, Lombardi, C. P., Rossi, E. D., Larocca, L. M., Schmitt, F., Fadda, G., Capodimonti, S., Luca, E., Bizzarro, T., Baltazar, F., Granja, S., Pontecorvi, A., Martini, M.   +30 more
core   +1 more source

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

The monocarboxylate transporter family—Role and regulation [PDF]

IUBMB Life, 2011
AbstractMonocarboxylate transporter (MCT) isoforms 1–4 catalyze the proton‐linked transport of monocarboxylates such as L‐lactate across the plasma membrane, whereas MCT8 and MCT10 are thyroid hormone and aromatic amino acid transporters, respectively.
Halestrap, AP, Wilson, MC
openaire   +3 more sources

Monocarboxylate Transporter 1 Deficiency and Ketone Utilization [PDF]

New England Journal of Medicine, 2014
Ketoacidosis is a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. We performed exome sequencing in a patient with recurrent, severe ketoacidosis and identified a homozygous frameshift mutation in the gene encoding monocarboxylate transporter 1 (SLC16A1, also called MCT1 ...
Hasselt, P.M. van, Ferdinandusse, S., Monroe, G.R., Ruiter, J.P., Turkenburg, M., Geerlings, M.J., Duran, K., Harakalova, M., Zwaag, B. van der, Monavari, A.A., Okur, I., Sharrard, M.J., Cleary, M., O'Connell, N., Walker, V., Rubio-Gozalbo, M.E., Vries, M.C. de, Visser, G., Houwen, R.H.J., Smagt, J.J. van der, Verhoeven-Duif, N.M., Wanders, R.J., Haaften, G. van   +22 more
openaire   +11 more sources

Sex Hormone-Dependent Regulation of Rat Hepatic Monocarboxylate Transporters Expression

, 2023
Proton-dependent monocarboxylate transporters (MCTs) are involved in monocarboxylate uptake and efflux in a range of biologically important tissues and barriers, including the liver, kidney, and blood-brain barrier (BBB) (1).
Felmlee, Melanie, Matthews, Tori, Zhang, Qing   +2 more
core   +1 more source

MCT4 has a potential to be used as a prognostic biomarker - a systematic review and meta-analysis

Oncology Reviews, 2019
The role of several metabolic changes, such as hypoxia and acidosis, in the tumour environment has caught the attention of researchers in cancer progression and invasion.
Arslaan Javaeed, Sanniya Khan Ghauri
doaj   +1 more source