Results 31 to 40 of about 1,538 (126)
Frontiers in Pharmacology, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday +3 more
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Major Intrinsic Proteins in Fungi: A Special Emphasis on the XIP Subfamily
Journal of FungiThe fungal kingdom, with an estimated five million species, has undergone extensive diversification over the past billion years and now occupies a wide array of ecological niches from terrestrial to aquatic ecosystems.
Jean-Stéphane Venisse +5 more
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Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound. [PDF]
PLoS ONE, 2012 Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many physiological functions. Aquaporin-based modulator drugs are predicted to be of broad potential utility in the treatment of several ...
Ana Paula Martins +8 more
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A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance
Small, EarlyView.Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib +10 more
wiley +1 more source
Biotechnology for Biofuels, 2019 Background Due to its inevitable formation during biodiesel production and its relatively high degree of reduction, glycerol is an attractive carbon source for microbial fermentation processes.
Maximilian R. Aßkamp +2 more
doaj +1 more source
Journal of Microscopy, EarlyView.Abstract Since its introduction 40 years ago, atomic force microscopy (AFM) has transformed nanoscale imaging across the physical and life sciences. In biology, AFM has provided unprecedented insights into nanoscale biomolecular organisation under near‐physiological conditions, revealing structures and interactions inaccessible to many conventional ...
Yueqi Wang +5 more
wiley +1 more source
Implication of Renal Aquaporin-3 in Fructose-Induced Metabolic Syndrome and Melatonin Protection [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Metabolic Syndrome (MetS) can be induced by ingestion of large amounts of fructose as a consequence of oxidative stress and dyslipidemia.
Suzy Fayez Ewida +1 more
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Journal of Applied Toxicology, Volume 46, Issue 11, Page 3868-3881, November 2026.ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima +4 more
wiley +1 more source
Analysis of aquaporin 9 expression in human epidermis and cultured keratinocytes
FEBS Open Bio, 2014 Aquaporin 9 (AQP9) is a member of the aquaglyceroporin family that transports glycerol, urea and other small solutes as well as water. Compared to the expression and function in epidermal keratinocytes of AQP3, another aquaglyceroporin, our knowledge of ...
Yoshinori Sugiyama +5 more
doaj +1 more source
The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker
Biomolecules, 2022 Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis ...
Inês V. da Silva +3 more
doaj +1 more source