Results 11 to 20 of about 1,538 (126)

Genome‐wide identification and solute selectivity of aquaporins in the sharpnose sevengill shark, Heptranchias perlo

Physiological Reports
The aquaporin genes (aqps) are widely distributed among vertebrates. In cartilaginous fish, aqp3 and aqp10 are duplicated, whereas many species have lost aqp8.
Shinichiro Hidaka, Ayumi Nagashima, Akira Kato   +2 more
doaj   +2 more sources

An Atypical Aquaporin 1 Derived From Paramecium multimicronucleatum Functions as a Multifunctional Channel That Permeates Water, Glycerol, and Urea. [PDF]

J Eukaryot Microbiol
ABSTRACT Although it had been reported that the translation product of the functional aquaporin gene, aqp1, is localized to the contractile vacuole complex of Paramecium multimicronucleatum, the molecules that pass through this channel protein had not been identified. In the present study, we introduced and expressed this protein in Xenopus oocytes and
Ishida M, Ueno S, Tominaga T, Tanaka K, Horikawa A, Hori M.   +5 more
europepmc   +2 more sources

Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap

Life, 2022
(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was ...
Katharina Geistlinger, Jana D. R. Schmidt, Eric Beitz   +2 more
doaj   +1 more source

Aquaporins in Pacific White Shrimp (Litopenaeus vannamei): Molecular Characterization, Expression Patterns, and Transcriptome Analysis in Response to Salinity Stress

Frontiers in Marine Science, 2022
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water and small solutes across cell membranes. These proteins are vital for maintaining water homeostasis in living organisms.
Zhongkai Wang, Yigeng Chen, Cong Wang, Nannan Zhao, Zhihao Zhang, Zhitong Deng, Yanting Cui, Renjie Wang, Yuquan Li   +8 more
doaj   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI-Oriented Perspective. [PDF]

Adv Sci (Weinh)
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Wilczok D, Valdés-Hernández J, Bernales V, Aspuru-Guzik A, Zhavoronkov A.   +4 more
europepmc   +2 more sources

Application of the Brown Dynamics Fluctuation-Dissipation Theorem to the Study of Plasmodium berghei Transporter Protein PbAQP

Frontiers in Physics, 2020
In this article, the Brownian dynamics fluctuation-dissipation theorem (BD-FDT) is applied to the study of transport of neutral solutes across the cellular membrane of Plasmodium berghei (Pb), a disease-causing parasite.
Liao Y. Chen
doaj   +1 more source

Boric acid transport activity of human aquaporins expressed in Xenopus oocytes

Physiological Reports, 2022
Boric acid is a vital micronutrient that is toxic at high concentrations in animals. However, the mechanisms underlying boric acid transport in animal cells remain unclear.
Kazutaka Ushio, Erika Watanabe, Takehiro Kamiya, Ayumi Nagashima, Tadaomi Furuta, Genki Imaizumi, Toru Fujiwara, Michael F. Romero, Akira Kato   +8 more
doaj   +1 more source

Endo-Porter–mediated delivery of phosphorodiamidate morpholino oligos (PMOs) in erythrocyte suspension cultures from Cope's gray treefrog Hyla chrysoscelis

BioTechniques, 2011
Cope's gray treefrog, Hyla chrysoscelis, is a freeze-tolerant anuran that accumulates cryoprotective glycerol during cold acclimation. H. chrysoscelis erythrocytes express the aquaglyceroporin HC-3, which facilitates transmembrane glycerol and water ...
Venkateshwar Mutyam, Matthew V. Puccetti, James Frisbie, David L. Goldstein, Carissa M. Krane   +4 more
doaj   +1 more source

Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases

Frontiers in Molecular Biosciences, 2022
Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol and other small uncharged solutes across cell membranes, have been recognized for their important role in human physiology and their involvement in multiple ...
Catarina Pimpão, Catarina Pimpão, Darren Wragg, Inês V. da Silva, Inês V. da Silva, Angela Casini, Graça Soveral, Graça Soveral   +7 more
doaj   +1 more source

Boric acid transport activity of marine teleost aquaporins expressed in Xenopus oocytes

Physiological Reports, 2023
Marine teleosts ingest large amounts of seawater containing various ions, including 0.4 mM boric acid, which can accumulate at toxic levels in the body. However, the molecular mechanisms by which marine teleosts absorb and excrete boric acid are not well
Shiori Kumagai, Erika Watanabe, Naoko Hayashi, Yuuri Kimura, Takehiro Kamiya, Ayumi Nagashima, Kazutaka Ushio, Genki Imaizumi, Juhyun Kim, Keijiro Munakata, Takahiro Umezawa, Shigehisa Hirose, Koji Kasai, Toru Fujiwara, Michael F. Romero, Akira Kato   +15 more
doaj   +1 more source