Results 201 to 210 of about 57,369 (303)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation. [PDF]

Brain Commun
Braun M, Simon MJ, Jang J, Sanderson K, Swierz J, Sevao M, Pincus AB, Schaser AJ, Elliott JE, Lim MM, Unni VK, Schindler AG, Keene CD, Latimer CS, Iliff JJ.   +14 more
europepmc   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Time-Resolved Epithelial Responses to ETEC-K88 Reveal Tryptophan-Linked Protection in IPEC-J2 Cells and Strain-Specific Intestinal Injury in Mice. [PDF]

Animals (Basel)
Hu Z, Yao Y, Chen S, Zhang S, Yin Y, Chen F, Tang X.   +6 more
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Aquaporin-4's dynamic expression and biological variations within the tumor obscure the paraneoplastic phenomenon in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder. [PDF]

Acta Neuropathol
Kothapalli NP, Guo Y, Vorasoot N, Wingerchuk DM, Flanagan EP, Dubey D, Tisavipat N, Cuascut FX, Patel HY, Lucchinetti CF, Pittock SJ.   +10 more
europepmc   +1 more source

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
María D. Girón, Manuel Manzano, Suzette L. Pereira, Antonio Reinoso, Chiara Burgio, Nora Montero‐Martin, Guillermo Jiménez‐Jiménez, Josep M. Argilés, Ricardo Rueda, José M. López‐Pedrosa, Rafael Salto   +10 more
wiley   +1 more source

Kidney-Based Molecular Diagnostics of Freshwater Drowning: Comparative Evaluation of SP-A2 and AQP5 in an Animal Model. [PDF]

Diagnostics (Basel)
Dervišević E, Osmanović H, Goletić T, Zuccarello P, Terzić I, Softić A, Ajanović Z, Bešić A, Sessa F.   +8 more
europepmc   +1 more source

Understanding environmental adaptation in intermediate wheatgrass

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Intermediate wheatgrass (IWG; Thinopyrum intermedium) is a perennial grain crop that offers many environmental benefits through extensive root systems in addition to food production. IWG's distribution across broad environmental gradients in Eurasia provides a model system for studying climate adaptation genetics essential for developing ...
Elizabeth Campbell‐Strupp, Anna Halpin‐McCormick, Jacob Jungers, Hannah Stoll, Brooke Bernhardt, Michael Kantar, Bryan Runck   +6 more
wiley   +1 more source