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Hydrocephalus and Aquaporins: The Role of Aquaporin-4

2011
Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is
A S, Filippidis   +2 more
openaire   +2 more sources

Aquaporins in cancer

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration.This review article summarizes our knowledge concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process.Tumor cells ...
RIBATTI, Domenico   +3 more
openaire   +3 more sources

Hydrocephalus and Aquaporins: The Role of Aquaporin-1

2011
Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is a major central nervous system disorder associated with defective cerebrospinal fluid (CSF) turnover. Aquaporin-1 (AQP1) is a water channel located mainly at the choroid plexus epithelium and plays an active role in CSF production.
M Y S, Kalani   +2 more
openaire   +2 more sources

Mechanosensitive aquaporins

Biophysical Reviews, 2023
Cellular systems must deal with mechanical forces to satisfy their physiological functions. In this context, proteins with mechanosensitive properties play a crucial role in sensing and responding to environmental changes. The discovery of aquaporins (AQPs) marked a significant breakthrough in the study of water transport.
Marcelo Ozu   +13 more
openaire   +3 more sources

Aquaporin Inhibitors

2023
Aquaporins (AQP) working as membrane channels facilitated water transport, play vital roles in various physiological progress including cell migration, energy metabolism, inflammation, etc. They are quite important drug targets, but elusive for discovery due to their undruggable properties.
Shuyuan, Wang   +2 more
openaire   +2 more sources

Aquaporins in Skin

2023
The skin is the largest organ of our body and plays a protective role against the external environment. The skin functions as a mechanical and water permeability barrier, assisting with thermoregulation and defending our body against a variety of stresses such as ultraviolet radiation, microbial infection, physical injuries, and chemical hazards.
Zhuming, Yin, Huiwen, Ren
openaire   +2 more sources

Aquaporins and placenta

2020
Water is the major component of cells and tissues. The fetal body consists of about 70-90% water and its fluid balance is dependent on the mother. In fact, abortion, premature birth, amniotic fluid volume abnormality, malformation and fetal growth restrictions might result when the homeostasis of the maternal-fetal fluid exchange is disrupted.
Antonio, Pérez-Pérez   +7 more
openaire   +2 more sources

Aquaporins in Eye

2023
The major part of the eye consists of water. Continuous movement of water and ions between the ocular compartments and to the systemic circulation is pivotal for many physiological functions in the eye. The movement of water facilitates removal of the many metabolic products of corneal-, ciliary body-, lens-, and retinal metabolism, while maintaining ...
Tran, Thuy Linh   +2 more
openaire   +3 more sources

Aquaporins in the Skin

2017
The skin is the largest organ of the body, serving as an important barrier between the internal milieu and the external environment. The skin is also one of the first lines of defense against microbial infection and other hazards, and thus, the skin has important immune functions .
Ravi, Patel   +3 more
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Epithelial aquaporins

Current Opinion in Cell Biology, 1998
The past year has brought significant advances in our understanding of the involvement of aquaporins in the regulation of water balance. Besides the identification of new mammalian aquaporins, highlights include the progress in our understanding of their cell-biological regulation and their roles in physiology and pathophysiology as deduced from ...
Deen, P.M.T., Os, C.H. van
openaire   +3 more sources

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