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Aquaporin Inhibitors

2023
Aquaporins (AQP) working as membrane channels facilitated water transport, play vital roles in various physiological progress including cell migration, energy metabolism, inflammation, etc. They are quite important drug targets, but elusive for discovery due to their undruggable properties.
Shuyuan, Wang   +2 more
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Cardiac aquaporins

Basic Research in Cardiology, 2013
Aquaporins are a group of proteins with high-selective permeability for water. A subgroup called aquaglyceroporins is also permeable to glycerol, urea and a few other solutes. Aquaporin function has mainly been studied in the brain, kidney, glands and skeletal muscle, while the information about aquaporins in the heart is still scarce.
Arkady, Rutkovskiy   +2 more
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Aquaporin gating

Current Opinion in Structural Biology, 2006
An acceleration in the rate at which new aquaporin structures are determined means that structural models are now available for mammalian AQP0, AQP1, AQP2 and AQP4, bacterial GlpF, AqpM and AQPZ, and the plant SoPIP2;1. With an apparent consensus emerging concerning the mechanism of selective water transport and proton extrusion, emphasis has shifted ...
Kristina, Hedfalk   +5 more
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Aquaporins in the Skin

2017
The skin is the largest organ of the body, serving as an important barrier between the internal milieu and the external environment. The skin is also one of the first lines of defense against microbial infection and other hazards, and thus, the skin has important immune functions .
Ravi, Patel   +3 more
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The structure of aquaporins

Quarterly Reviews of Biophysics, 2006
1. Introduction 3621.1 The elusive water pores 3621.2 CHIP28 3622. Studies on AQP-1 3632.1 Expression of AQP1 cDNA in Xenopus oocytes 3632.2 Reconstitution of purified AQP1 into artificial lipid bilayers 3642.3 Structural information deduced from the primary sequence 3652.4 Evolution and mammalian AQPs 3653.
Tamir, Gonen, Thomas, Walz
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Plant aquaporins

Physiologia Plantarum, 2002
Aquaporins are ubiquitous membrane channel proteins that facilitate and regulate the permeation of water across biological membranes. Aquaporins are members of the MIP family and some of them seem to be also able to transport other molecules such as urea or glycerol.
Isabel, Baiges   +3 more
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What Are Aquaporins For?

Journal of Membrane Biology, 2004
The prime function of aquaporins (AQPs) is generally believed to be that of increasing water flow rates across membranes by raising their osmotic or hydraulic permeability. In addition, this applies to other small solutes of physiological importance.
A E, Hill   +2 more
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Aquaporins in Obesity

2017
Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance and diabetes , dyslipidemia and hypertension , collectively named Metabolic Syndrome.
Inês V, da Silva, Graça, Soveral
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Increased Expression of Aquaporin-1 and Aquaporin-3 in Pterygium

Cornea, 2013
Recent studies have shown that aquaporins (AQPs) play an important role in proliferating tumor microvessels and angiogenesis. In this study, the authors investigated the expression of aquaporin-1 (AQP1) and aquaporin-3 (AQP3) in pterygial and normal conjunctival tissues.Fifteen patients with pterygium were enrolled in the study.
Demir, Selim   +3 more
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Aquaporins in the Eye

2017
The major part of the eye consists of water . Continuous movement of water and ions between the ocular compartments and to the systemic circulation is pivotal for many physiological functions in the eye. The movement of water facilitates removal of the many metabolic products of corneal-, ciliary body-, lens- and retinal metabolism, while maintaining ...
Tran, Thuy Linh   +2 more
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