Results 21 to 30 of about 204,022 (214)

Alternative Complement Pathway Inhibition by Lampalizumab

Ophthalmology Science, 2023
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS, Verena Steffen, MSc, Lee A. Honigberg, PhD, Michael C. Chang, PhD   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Influence of Water‐Compatible Binder Systems on Physical and Electrochemical Performance of LiFePO4‐Based Positive Electrodes: A Comparative Study

Advanced Energy & Sustainability Research
The sustainability of lithium‐ion battery (LIB) production can be improved by implementing aqueous processing for positive electrodes, as already practiced for negative electrodes.
Chirag Vankani, Atif Javed, Martin Winter, Markus Börner   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Bulk and Surface Reactivity of LiNi0.5Mn1.5O4 in Contact with (Acidic) Water

Advanced Energy & Sustainability Research
Lithium‐ion battery cathode materials such as LiNi0.5Mn1.5O4 (LNMO) are very sensitive to water, which has so far hindered the successful commercialization of aqueous electrode processing strategies.
Annika R. Schuer, Matthias Kuenzel, Maider Zarrabeitia, Tobias Eisenmann, Chengping Li, Sylvio Indris, Michael Knapp, Volodymyr Baran, Ralph Gilles, Dorin Geiger, Ute Kaiser, Philipp Scheitenberger, Mika Lindén, Peter Axmann, Margret Wohlfahrt‐Mehrens, Stefano Passerini, Dominic Bresser   +16 more
doaj   +1 more source

Chlorogenic acid removal during aqueous processing of sunflower kernels

Grasas y Aceites, 1993
The effect of incorporating specific stages to remove phenolic compounds during aqueous processing of sunflower, to obtain oil of good quality and meal of light color was studied. The aqueous process removes 88 % of the chlorogenic acid initially present
H. Domínguez, M. J. Núñez, J. M. Lema
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Understanding Aqueous Processing of Positive Electrodes for Lithium Ion Batteries: Investigation of the Interaction Mechanism of LiNi0.8Mn0.1Co0.1O2 with Water via a D2O Treatment Approach

Advanced Energy & Sustainability Research
Aqueous processing of nickel‐rich layered oxide active materials for positive electrodes, while attractive, possesses multiple obstacles not encountered when using state‐of‐the‐art methods.
Joshua Engler, Alexandros Tsoufios, Martin Winter, Markus Börner, Simon Wiemers‐Meyer, Sascha Nowak   +5 more
doaj   +1 more source

Impact of Aerosol-Cloud Cycling on Aqueous Secondary Organic Aerosol Formation

Atmosphere, 2019
Chemical processing of organic material in aqueous atmospheric aerosols and cloudwater is known to form secondary organic aerosols (SOA), although the extent to which each of these processes contributes to total aerosol mass is unclear. In this study, we
William G. Tsui, Joseph L. Woo, V. Faye McNeill   +2 more
doaj   +1 more source