Results 41 to 50 of about 204,022 (214)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Enabling Aqueous Processing of Ni‐Rich Layered Oxide Cathodes via Systematic Modification of Biopolymer (Polysaccharide)‐Based Binders

Advanced Energy & Sustainability Research
Aqueous processing of lithium (ion) battery cathodes based on Ni‐rich layered oxides like LiNi0.83Co0.12Mn0.05O2 (NCM) can reduce costs, increase sustainability, and pave the way for F‐free, e.g., biopolymeric binders, however, the degradation of water ...
Simon Albers, Jens Timmermann, Tobias Brake, Anindityo Arifiadi, Anna I. Gerlitz, Markus Börner, Martin Winter, Johannes Kasnatscheew   +7 more
doaj   +1 more source

The Influence of Sedimentation on the Composition of the Lipoaspirate and the Effects on Further Mechanical Processing

Cells
Manual processing of lipoaspirate can enhance stem cell concentration, thereby improving the take rate, which still represents a major challenge in autologous fat transfer.
Andreas Eigenberger, Oliver Felthaus, Alexander Bartsch, Tom Schimanski, Kirsten Utpatel, Lukas Prantl   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Study of Aqueous and Non-Aqueous Phase Liquid in Fractured Double-Porosity Soil Using Digital Image Processing

Geologia Croatica, 2018
The leakage and spillage of non-aqueous phase liquids (NAPLs) and aqueous phase liquids (APLs) contribute to groundwater contamination, resulting in groundwater pollution and rendering the quality of groundwater unsafe for drinking and agriculture ...
Loke Kok Foong, Norhan Abd Rahman, Ramli Nazir, Roland W. Lewis   +3 more
doaj   +1 more source

Silicon Substrate Treated with Diluted NaOH Aqueous for Si/PEDOT: PSS Heterojunction Solar Cell with Performance Enhancement

Energies, 2020
Si/PEDOT: PSS solar cell is an important alternative for photovoltaic device due to its anticipated high theoretical efficiency and simple manufacturing process.
Tao Chen, Hao Guo, Leiming Yu, Tao Sun, Yu Yang   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of Water-Based and Underwater Assistance Methods on the Hole Quality of Silicon Nitride Ceramics Using a Picosecond Laser

Micromachines
This study investigated the effects of water-based and underwater assistance methods on the quality of picosecond laser-drilled microholes in silicon nitride ceramics, analyzing the influence of laser power variations in air and aqueous environments on ...
Jie Zhang, Liang Wang, Yongchao Shi, Song Yao, Kaibo Xia   +4 more
doaj   +1 more source