Results 91 to 100 of about 407,477 (350)
An Overview on the Recent Technologies and Advances in Drug Delivery of Poorly Water-Soluble Drugs
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2019 Solubility can be defined as the amount of solute dissolved in a solvent at certain conditions to yield a single-phase system. Solubility of active pharmaceutical ingredients is considered the main parameter to get the most desired drug concentration in
Ibtihal Abdul kadhim Dakhil +1 more
doaj +1 more source
Aqueous Solubility of Some Natural Phenolic Compounds [PDF]
Industrial & Engineering Chemistry Research, 2008 In this work, the aqueous solubilities of two hydroxybenzoic acids (gallic and salicylic acid) and three phenylpropenoic acids (trans-cinnamic, ferulic, and caffeic acids) are addressed. Measurements were performed, as a function of temperature, between 288.15 and 323.15 K, using the shake-flask method for generating the saturated aqueous solutions ...
Mota, Fátima L. +3 more
openaire +3 more sources
On the Stabilizing Action of Protein Denaturants: Acetonitrile Effect on Stability of Lysozyme in Aqueous Solutions [PDF]
, 2000 Stability of hen lysozyme in the presence of acetonitrile (MeCN) at different pH values of the medium was studied by scanning microcalorimetry with a special emphasis on determination of reliable values of the denaturational heat capacity change.
Kovriguine, Evgueni, Potekhin, Sergey A.
core +2 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Modeling Nucleation and Growth of Zinc Oxide During Discharge of Primary Zinc-Air Batteries [PDF]
, 2017 Metal-air batteries are among the most promising next-generation energy storage devices. Relying on abundant materials and offering high energy densities, potential applications lie in the fields of electro-mobility, portable electronics, and stationary ...
Horstmann, Birger +3 more
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Hydrophobically modified polyelectrolytes as potential drugs reservoirs of n-alkyl-nitroimidazoles [PDF]
, 2007 Indexación: ScieloThe solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different ...
Acevedo, Betsabé +3 more
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A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari +3 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan +7 more
wiley +1 more source
Lithium-salt monohydrate melt: A stable electrolyte for aqueous lithium-ion batteries
Electrochemistry Communications, 2019 Concentrated aqueous electrolytes are promising for high-voltage and safe aqueous lithium-ion batteries because of their wide potential window. For Li system, a room-temperature dihydrate melt (27.8 mol kg−1) has been demonstrated to function as a stable
Seongjae Ko +9 more
doaj +1 more source