Results 101 to 110 of about 2,054,242 (350)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]

, 2006
The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
A.A. Hernandez Santiago, Coffman, Coffman, D.B. Davies, Datta, Davies, Evstigneev, Evstigneev, Fawzi, Hussain, Jain, Khalil, Larsen, Lim, M.P. Evstigneev, Rasool, Redenti, Ribeiro, V.P. Evstigneev, Veselkov, Veselkov, Veselkov, Veselkov   +22 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Extreme learning machine-based model for Solubility estimation of hydrocarbon gases in electrolyte solutions [PDF]

arXiv, 2019
Calculating hydrocarbon components solubility of natural gases is known as one of the important issues for operational works in petroleum and chemical engineering. In this work, a novel solubility estimation tool has been proposed for hydrocarbon gases including methane, ethane, propane, and butane in aqueous electrolyte solutions based on extreme ...
arxiv  

Accurate, reliable and interpretable solubility prediction of druglike molecules with attention pooling and Bayesian learning [PDF]

arXiv, 2022
In drug discovery, aqueous solubility is an important pharmacokinetic property which affects absorption and assay availability of drug. Thus, in silico prediction of solubility has been studied for its utility in virtual screening and lead optimization.
arxiv  

Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. [PDF]

, 2016
PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family.
Cabrera, Andrea P, Ghosh, Kaustabh, Gorham, Ronald D, Harrison, Reed ES, Johnson, Lincoln V, Mohan, Rohith R, Morikis, Dimitrios   +6 more
core   +1 more source

Is experimental data quality the limiting factor in predicting the aqueous solubility of druglike molecules?

Molecular Pharmaceutics, 2014
We report the results of testing quantitative structure-property relationships (QSPR) that were trained upon the same druglike molecules but two different sets of solubility data: (i) data extracted from several different sources from the published ...
David S. Palmer, John B. O. Mitchell
semanticscholar   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

An Overview on the Recent Technologies and Advances in Drug Delivery of Poorly Water-Soluble Drugs

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2019
Solubility can be defined as the amount of solute dissolved in a solvent at certain conditions to yield a single-phase system. Solubility of active pharmaceutical ingredients is considered the main parameter to get the most desired drug concentration in
Ibtihal Abdul kadhim Dakhil, Zainab H. Mahdi   +1 more
doaj   +1 more source

Aqueous Solubility Enhancement of Mirtazapine: Effect of Cosolvent and Surfactant

, 2015
The poor aqueous solubility of drugs is a challenging problem faced by pharmaceutical scientists in drug formulation. Cosolvency and micellization techniques have been severally used to enhance the solubility of poorly aqueous soluble drugs. Mirtazapine,
Kenneth E. Ezealisiji, Mbah Cj, P. O. Osadebe   +2 more
semanticscholar   +1 more source