Intrinsic Aqueous Solubility: Mechanistically Transparent Data-Driven Modeling of Drug Substances [PDF]
Pharmaceutics, 2022 Intrinsic aqueous solubility is a foundational property for understanding the chemical, technological, pharmaceutical, and environmental behavior of drug substances.
Mare Oja +3 more
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Precise heteroatom doping determines aqueous solubility and self-assembly behaviors for polycyclic aromatic skeletons [PDF]
Communications Chemistry, 2022 Enhancing the hydrophilicity of hydrophobic molecular scaffolds allows to increase their aqueous solubility and therefore their usability for a range of applications.
Kang Li +4 more
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Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog [PDF]
Scientific Reports, 2021 Decreasing the partition coefficient (LogP) by the introduction of a hydrophilic group is the conventional approach for improving the aqueous solubility of drug candidates, but is not always effective. Since melting point is related to aqueous solubility,
Junki Morimoto +6 more
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Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs? [PDF]
ADMET and DMPK, 2020 The aim of the study was to explore to what extent small molecules (mostly from the Rule of 5 chemical space) can be used to predict the intrinsic aqueous solubility, S0, of big molecules from beyond the Rule of 5 (bRo5) space.
Alex Avdeef, Manfred Kansy
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Improving Aqueous Solubility of Natural Antioxidant Mangiferin through Glycosylation by Maltogenic Amylase from Parageobacillus galactosidasius DSM 18751. [PDF]
Antioxidants (Basel), 2021 Wu JY +5 more
europepmc +3 more sources
Influence of Choline-Based Ionic Liquids as Neoteric Green Solvents on Aqueous Solubility of Lamotrigine and Piroxicam Drugs [PDF]
Pharmaceutical Sciences, 2022 Background: New compounds called choline-based ionic liquids (ILs) that are environmentally friendly have become more attractive. In this study, some choline-based ILs (choline lactate (ChLa) and choline propionate (ChPro)) have been used to increase the
Hemayat Shekaari +3 more
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Solubility Enhancement of Betamethasone, Meloxicam and Piroxicam by Use of Choline-Based Deep Eutectic Solvents [PDF]
Pharmaceutical Sciences, 2021 Background: The low aqueous solubility of three important drugs (betamethasone (BETA), meloxicam (MEL) and piroxicam (PIR)) have been increased by use of deep eutectic solvents (DESs) based choline chloride/urea (ChCl/U), choline chloride/ethylene glycol
Salva Golgoun +2 more
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Use of GA-ANN and GA-SVM for a QSPR study on the aqueous solubility of pesticides [PDF]
Journal of the Serbian Chemical Society, 2021 The partitioning tendency of pesticides, in this study herbicides in particular, into different environmental compartments depends mainly of the physicochemical properties of the pesticides itself.
Bouakkadia Amel +4 more
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Solubility models of CH4, CO2, and noble gases and their geological applications
Journal of Natural Gas Geoscience, 2023 Solubility models for CH4, CO2, and noble gases are widely used in Earth Sciences, playing pivotal roles in the study of homogenization pressure of inclusions, paleoclimate variation, gas migration and accumulation, formation of helium-rich gas plays ...
Xiangrui Chen +3 more
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Cyclodextrins: Concept to applications, regulatory issues and challenges [PDF]
Nanomedicine Research Journal, 2020 Background: Solubility properties of drugs intensify a crucial role during the formulation development process. Aqueous solubility is one of the most significant factors concerning drug bioavailability analysis.
Azeez Mohammad +2 more
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