Results 21 to 30 of about 2,054,242 (350)
Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
Pharmaceuticals, 2021 One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor ...
Bharti Gupta +4 more
doaj +1 more source
Aqueous Solubility of Hydrocarbon Mixtures [PDF]
Revue de l'Institut Français du Pétrole, 1998 The solubility of hydrocarbon components in water is of great importance for the environmental sciences. Its prediction is usually based on using the pure component solubilities and the mole fraction of the components in the mixture. While the pure component solubilities are generally well known, few data exist on the solubility of mixtures.
de Hemptinne, J. C. +3 more
openaire +2 more sources
Future Journal of Pharmaceutical Sciences, 2020 Background High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. This hampers their oral
Pragya Baghel +4 more
doaj +1 more source
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]
, 2016 The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar +5 more
core +2 more sources
Design and in Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin [PDF]
, 2013 Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties.
El-Sherbiny, Ibrahim M. +3 more
core +2 more sources
Advanced Engineering Materials, EarlyView., 2023 A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal +3 more
wiley +1 more source
Inclusion complexes of pesticides in aqueous solutions of methylated-β-cyclodextrin [PDF]
Hemijska Industrija, 2013 Disadvantage of some organic pesticides is their low water solubility. Among other substances, cyclodextrins and modified cyclodextrins were considered as agents for improving pesticides water solubility.
Petrović Goran M. +5 more
doaj +1 more source
Predicting small molecules solubilities on endpoint devices using deep ensemble neural networks [PDF]
, 2023 Aqueous solubility is a valuable yet challenging property to predict. Computing solubility using first-principles methods requires accounting for the competing effects of entropy and enthalpy, resulting in long computations for relatively poor accuracy.
arxiv +1 more source
Scientific Data, 2019 Water is a ubiquitous solvent in chemistry and life. It is therefore no surprise that the aqueous solubility of compounds has a key role in various domains, including but not limited to drug discovery, paint, coating, and battery materials design ...
Murat Cihan Sorkun +2 more
semanticscholar +1 more source
Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]
, 2010 Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Autret, Jean Marie +3 more
core +1 more source