Measurement and Modeling of Solubility of Galactose in Aqueous Ionic Liquids, 1-Butyl-3-Methyl Imidazolium Bromide, 1-Hexyl-3-Methyl Imidazolium Bromide and 1-Butyl-3-Methylimidazolium Chloride at T = (298.15 And 308.15) K [PDF]
Pharmaceutical Sciences, 2019 Background: Saccharides are considered as abundant, cheap and renewable starting materials for chemicals and fuels. Recently, ionic liquids have been used as green solvents for saccharides.
Mohammad Taghi Zafarani Moattar +2 more
doaj +1 more source
Molecules, 2022 New protocol for screening efficient and environmentally friendly solvents was proposed and experimentally verified. The guidance for solvent selection comes from computed solubility via COSMO-RS approach.
Maciej Przybyłek +3 more
doaj +1 more source
ADME prediction with KNIME: A retrospective contribution to the second “Solubility Challenge”
ADMET and DMPK, 2021 Computational models for predicting aqueous solubility from the molecular structure represent a promising strategy from the perspective of drug design and discovery.
Gabriela Falcón-Cano +2 more
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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
Pharmaceuticals, 2021 One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor ...
Bharti Gupta +4 more
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Prediction of aqueous solubility from SCRATCH [PDF]
International Journal of Pharmaceutics, 2010 This study proposes the SCRATCH model for the aqueous solubility estimation of a compound directly from its structure. The algorithm utilizes predicted melting points and predicted aqueous activity coefficients. It uses two additive, constitutive molecular descriptors (enthalpy of melting and aqueous activity coefficient) and two non-additive molecular
Parijat, Jain, Samuel H, Yalkowsky
openaire +2 more sources
Future Journal of Pharmaceutical Sciences, 2020 Background High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. This hampers their oral
Pragya Baghel +4 more
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ADMET and DMPK, 2020 In-silico prediction of aqueous solubility plays an important role during the drug discovery and development processes. For many years, the limited performance of in-silico solubility models has been attributed to the lack of high-quality solubility data
Gabriela Falcón-Cano +2 more
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Self-assembly of Tween 80 micelles as nanocargos for oregano and trans-cinnamaldehyde plant-derived compounds [PDF]
, 2020 The self-assembly of Tween 80 (T80) micelles loaded with plant-based oregano essential oil (OR) and trans-cinnamaldehyde (TCA) was studied. The effect of different factors, including the surfactant to oil ratio, the presence of sodium chloride, thermal ...
Claeys, Myriam +4 more
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Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]
, 2016 The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar +5 more
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Design and in Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin [PDF]
, 2013 Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties.
El-Sherbiny, Ibrahim M. +3 more
core +2 more sources