Results 291 to 300 of about 407,477 (350)

Modeling Aqueous Solubility

Journal of Chemical Information and Computer Sciences, 2003
This paper describes the development of an aqueous solubility model based on solubility data from the Syracuse database, calculated octanol-water partition coefficient, and 51 2D molecular descriptors. Two different statistical packages, SIMCA and Cubist, were used and the results were compared.
Darko, Butina, Joelle M R, Gola
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Aqueous solubility of permethylsiloxanes (silicones)

Environmental Toxicology and Chemistry, 1996
Abstract The aqueous solubility of several low mlecular weight linear, cyclic, and branched permethylsiloxanes was determined at room temperature. A method for preparing molecularly dispersed, colloid-free saturated aqueous solutions is described.
Sudarsanan Varaprath, Cecil L. Frye, Jerry Hamelink   +2 more
openaire   +1 more source

Solubility Determination of Barely Aqueous-Soluble Organic Solids

Journal of Pharmaceutical Sciences, 1979
Solubility determination of organic molecules having very low solubilities is hampered by such problems as slow equilibration during measurement, influence of impurities, and inherent heterogeneity in the energetic content of the crystalline solid. Three approaches to meeting these problems are presented.
T, Higuchi, F M, Shih, T, Kimura, J H, Rytting   +3 more
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Aqueous solubility of chloroguaiacols

Journal of Chemical & Engineering Data, 1994
The aqueous solubilities of guaiacol (2-methoxyphenol) and seven chlorinated guaiacols are reported at 25 o C, and for five of these over a temperature range from 5 to 45 o C, from which the enthalpies of solution are deduced. It is shown that the solubilities are well corrected with molar volume and that chlorinated phenols and guaiacols follow ...
Deborah Tam, Dana Varhanickova, Wan Ying Shiu, Donald Mackay   +3 more
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Dioxygen solubility in aqueous phosphatidylcholine dispersions

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1991
The solubility of molecular oxygen, or dioxygen, in low weight percent (1.5%) sonicated dimyristoylphosphatidylcholine (DMPC) aqueous dispersions saturated with air has been measured as a function of temperature between 10 degrees C and 40 degrees C.
E S, Smotkin, F T, Moy, W Z, Plachy
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Soluble mucins in human aqueous tears

Biochemical Society Transactions, 1997
Nine mucin genes have been identified in non-ocular tissues. The many mucin gene products share a common structure with highly glycosylated variable number tandem repeat (VNTR) regions separated by naked nonVNTR regions [ 1,2]. How mucin structure relates to their function in the tear film awaits definitive characterisation of the mucins.
Ellingham, RB, Myerscough, N, Gout, II, Berry, MS, Corfield, AP   +4 more
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Solubility of Doxycycline in Aqueous Solution

Journal of Pharmaceutical Sciences, 1979
The solubility of doxycyline monohydrate and doxycycline hydrochloride dihydrate was investigated in aqueous solution. The hydrochloride dihydrate salt was isolated and identified from solutions initially containing doxycycline hyclate in water.
J B, Bogardus, R K, Blackwood
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Aqueous Solubility of 14C‐Triamcinolone Acetonide

Journal of Pharmaceutical Sciences, 1976
The blue tetrazolium colorimetric assay has often been employed in the analysis of corticosteroids. However, the reaction between blue tetrazolium and corticosteroids partly depends on the apparent pH of the system. In an earlier study of the temperature dependence of the solubility and dissolution of triamcinolone acetonide in aqueous dissolution ...
C R, Behl, L H, Block, M L, Borke
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Predicting aqueous solubility from structure

Drug Discovery Today, 2005
The aqueous solubility of a drug is one of the key physical properties that affect both its ADME profile and 'screenability' in HTS. This review critically surveys a range of methods that can be used to predict the solubility of a compound in water and presents some of the main issues that affect the applicability of different techniques.
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Recent Advances on Aqueous Solubility Prediction

Combinatorial Chemistry & High Throughput Screening, 2011
Aqueous solubility is one of the major physiochemical properties to be optimized in drug discovery. It is related to absorption and distribution in the ADME-Tox (Absorption, Distribution, Metabolism, Excretion, and Toxicity). Aqueous solubility and membrane permeability are the two key factors that affect a drug's oral bioavailability.
Junmei, Wang, Tingjun, Hou
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