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Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules [PDF]
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability ...
Dave, Vivek S+4 more
core +2 more sources
In this study, whey protein isolate (WPI) was employed to increase the water dispersibility of curcumin using a solvent‐free pH shifting method (pH 12 to pH values of 7.0 and 3.0).
Hossein Taghavi Kevij+2 more
semanticscholar +1 more source
Solubility of hydrogen in aqueous solutions of sodium and potassium bicarbonate from 293 to 333 K [PDF]
An experimental study is presented of the hydrogen solubility in aqueous salt solutions containing sodium and potassium bicarbonate from 293 to 333 K. For this purpose, gas consumption measurements have been performed by determining the ultimate pressure
Engel, D.C.+2 more
core +2 more sources
High-pressure microfluidization is used to prepare a series of oil-in-water Pickering nanoemulsions using sterically-stabilized diblock copolymer nanoparticles as the Pickering emulsifier. The droplet phase comprised either n-octane, n-decane, n-dodecane,
K. L. Thompson+3 more
semanticscholar +1 more source
Oil-in-water emulsions contain the inner oil phase, the protein membrane at the interface and the aqueous phase. In this study, the spatial partition of resveratrol was investigated in sunflower oil, fish oil, medium-chain triglyceride (MCT) and ...
Yang Chen, Hao Cheng, Li Liang
doaj +1 more source
Direct calculation of the planar NaCl-aqueous solution interfacial free energy at the solubility limit [PDF]
Salty water is the most abundant electrolyte aqueous mixture on Earth, however, very little is known about the NaCl-saturated solution interfacial free energy. Here, we provide the first direct estimation of this magnitude for several NaCl crystallographic planes by means of the Mold Integration technique, a highly efficient computational method to ...
arxiv +1 more source
Selective removal of H2S from sour gases with microporous membranes. Part II. A liquid membrane of water-free tertiary amines [PDF]
In the present study the application of a liquid membrane for selective removal of H2S from gases also containing CO2 was investigated. The liquid membrane was filled with pure methyl-di-ethanol-amine (MDEA). A theoretical model was developed to describe:
Kreulen, H.+3 more
core +3 more sources
Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT).
K. Bachovchin+15 more
semanticscholar +1 more source
Rhenium solubility and speciation in aqueous fluids at high temperature and pressure
In order to characterize rhenium transport via infiltration of fluids in the Earth's interior, the solubility and solution mechanisms of ReO2 in aqueous fluids were determined to 900 °C and about 1710 MPa by using an externally–heated hydrothermal ...
Bjorn Mysen
doaj +1 more source
Synthesis of Purine-Based Ionic Liquids and Their Applications
Bio-based ionic liquids (ILs) are being increasingly sought after, as they are more sustainable and eco-friendly. Purines are the most widely distributed, naturally occurring N-heterocycles, but their low water-solubility limits their application.
Ana R. F. Carreira+8 more
doaj +1 more source