Results 51 to 60 of about 2,054,242 (350)
Physics-Guided Continual Learning for Predicting Emerging Aqueous Organic Redox Flow Battery Material Performance [PDF]
, 2023 Aqueous organic redox flow batteries (AORFBs) have gained popularity in renewable energy storage due to their low cost, environmental friendliness and scalability. The rapid discovery of aqueous soluble organic (ASO) redox-active materials necessitates efficient machine learning surrogates for predicting battery performance.
arxiv +1 more source
Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K [PDF]
Pharmaceutical Sciences, 2019 Background: To overcome low solubility of naproxen (NAP), deep eutectic solvents (DESs) based on choline chloride (ChCl) with glycerol (G) and oxalic acid (OA) as green solvents have been used up to 0.9 mole fraction of DES at T = (298.15 to 313.15)
Masumeh Mokhtarpour +3 more
doaj +1 more source
Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV [PDF]
arXiv, 2023 Solubility and interfacial energy are two fundamental parameters underlying the competitive nucleation of polymorphs. However, solubility measurement of metastable phases comes with a risk of solventmediated transformations which can render the results unreliable.
arxiv
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]
, 2014 BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core +2 more sources
Prediction of aqueous solubility from SCRATCH [PDF]
International Journal of Pharmaceutics, 2010 This study proposes the SCRATCH model for the aqueous solubility estimation of a compound directly from its structure. The algorithm utilizes predicted melting points and predicted aqueous activity coefficients. It uses two additive, constitutive molecular descriptors (enthalpy of melting and aqueous activity coefficient) and two non-additive molecular
Parijat Jain, Samuel H. Yalkowsky
openaire +3 more sources
Journal of Medicinal Chemistry, 2017 Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes.
J. Fiorito +8 more
semanticscholar +1 more source
COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA
Química NovaPharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability.
Alanny B. O. Rocha +10 more
doaj +1 more source
Pharmaceutical development and technology (Print), 2017 This article investigates the aqueous solubility of the poorly soluble drug candesartan cilexetil (CC) in the presence of poly(amidoamine) (PAMAM) dendrimers. The effect of variables such as concentration, generation size (G2–G4), and surface groups (NH2,
A. Ertürk, M. Gürbüz, M. Tülü
semanticscholar +1 more source
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
Biomedicines, 2022 The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with
Dixit V. Bhalani +3 more
semanticscholar +1 more source
Asian Journal of Pharmaceutical Sciences, 2014 Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.
Prakash Khadka +8 more
doaj +1 more source