Results 51 to 60 of about 35,695,125 (238)

Direct Purification of Pectinase from Mango (Mangifera Indica Cv. Chokanan) Peel Using a PEG/Salt-Based Aqueous Two Phase System

Molecules, 2011
An Aqueous Two-Phase System (ATPS) was employed for the first time for the separation and purification of pectinase from mango (Mangifera Indica Cv. Chokanan) peel. The effects of different parameters such as molecular weight of the polymer (polyethylene
Abdul Manap Mohd Yazid, Shuhaimi Mustafa, Md. Zaidul Islam Sarker, Amid Mehrnoush   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Dampness and moulds in relation to respiratory and allergic symptoms in children : results from phase two of the International Study of Asthma and Allergies in Childhood, (ISAAC Phase Two) [PDF]

, 2013
Many studies report that damp housing conditions are associated with respiratory symptoms. Less is known about mechanisms and possible effect modifiers. Studies of dampness in relation to allergic sensitization and eczema are scarce.
Wickens, Kristin L., Gehring, Ulrike, Genuneit, Jon, Kleiner, Andrea, Crane, Julian, Siebers, Rob, Buchele, Gisela, Montefort, Stephen, Brunekreef, Bert, ISAAC Phase Two Study Group, Strachan, David P.   +10 more
core   +1 more source

Aqueous Two-Phase System (ATPS) Technique

, 2023
 Aqueous two-phase system (ATPS), also known as all-aqueous system, is formed by phase separation of an aqueous mixture containing two incompatible polymers, or one polymer and other salts above critical concentrations.
Alex Brown (15300919)
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hydrophobic ionic liquids-assisted polymer recovery during penicillin extraction in aqueous two-phase system

, 2009
In this study, terminal modified poly(ethylene glycerol) (PEG) was employed as the phase-forming polymer to construct aqueous two-phase (ATP). After the phase equilibrium, 95.8% penicillin could be extracted into imidazole-terminal PEG-rich phase ...
Xia, Hansong, Guo, Chen, Yu, J, Liu, Huizhou, Yu, Jiang, Jiang, Yangyang   +5 more
core   +1 more source

Application of Aqueous Two-Phase System in the Extraction of Invertase Enzyme from Potato Tubers Using PEG8000/Potassium Phosphate

Al-Khawarizmi Engineering Journal
An aqueous two-phase system (ATPS) is a clean alternative for traditional aqueous-organic solvent extraction systems. This technique has proven to be highly effective for extracting and separating mixtures of biomolecules.
Meaad Kadhim, Khalid Hameed, Hameed Mahood   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source