Results 41 to 50 of about 6,673 (263)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

The Crisis Management of the Political Phenomenon of the Khawārij During the Rule of Amīr al-Muʾminīn (PBUH) Based on Content Analysis Method [PDF]

مطالعات قرآن و حدیث
Although numerous studies have been conducted so far on the actions and views of Imām ʿAlī (PBUH) regarding the Khawārij, it seems that one of the needs of the Islamic society today is to analyze and outline what the management model and leadership ...
Mahdi Taghavi Rafsanjani
doaj   +1 more source

THE RIGHT TO SELF-DEFENSE AS A CONSTITUTIONAL HUMAN RIGHT: PROBLEMS OF THEORY AND PRACTICE [PDF]

Северо-Кавказский юридический вестник, 2019
In this article the author considers the constitutional right to self-defense. This right is directly derived from the meaning of P. 2 of Art. 45 of the Constitution of the Russian Federation, although there is no legislative definition of the right to ...
Еремейчук Михаил Владимирович
doaj   +1 more source

Skinning arbitrary deformations [PDF]

Proceedings of the 2007 symposium on Interactive 3D graphics and games, 2007
Matrix palette skinning (also known as skeletal subspace deformation) is a very popular real-time animation technique. So far, it has only been applied to the class of quasi-articulated objects, such as moving human or animal figures. In this paper, we demonstrate how to automatically construct skinning approximations of arbitrary precomputed ...
Ladislav Kavan, Rachel McDonnell, Simon Dobbyn, Jirí Zára, Carol O'Sullivan   +4 more
openaire   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

De quoi l’héroïsme est-il le nom dans No Name de Wilkie Collins et A Tale of Two Cities de Charles Dickens ?

Cahiers Victoriens et Edouardiens, 2014
The reader may wonder about the fate of Sydney Carton in A Tale of Two Cities by Charles Dickens and about the fate of Magdalen Vanstone in No Name by Wilkie Collins. The question of their heroism is at stake.
Sophie Naveau
doaj   +1 more source

Classes of Arbitrary Kind

, 2018
The type class system in the Haskell Programming language provides a useful abstraction for a wide range of types, such as those that support comparison, serialization, ordering, between others. This system can be extended by the programmer by providing custom instances to one’s custom types. Yet, this is often a monotonous task.
Serrano, Alejandro, Miraldo, Victor Cacciari   +1 more
openaire   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

‘Transnationalising’ Ne Bis In Idem: How the Rule of Ne Bis In Idem Reveals the Principle of Personal Legal Certainty

Utrecht Law Review, 2013
Since Article 54 of the Convention implementing the Schengen Agreement gave the rule of ne bis in idem a transnational dimension, talk of the ‘transnational ne bis in idem principle’ has been commonplace.
Juliette Lelieur
doaj   +1 more source