Results 31 to 40 of about 13,745 (217)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Costs of hospital admissions due to COVID-19 in the federal capital of Brazil: a study based on hospital admission authorizations

Brazilian Journal of Infectious Diseases
This is a cost analysis study based on hospital admissions, conducted from the perspective of the Brazilian Unified Health System (SUS), carried out in a cohort of patients hospitalized at the University Hospital of Brasília (UHB) due to Severe Acute ...
Ana Carolina Esteves da Silva Pereira, Luciana G. Gallo, Ana Flávia de M. Oliveira, Maria Regina F. de Oliveira, Henry M. Peixoto   +4 more
doaj   +1 more source

Changes in the Transmission Dynamic of Chikungunya Virus in Southeastern Senegal

Viruses, 2020
In Senegal, chikungunya virus (CHIKV) is maintained in a sylvatic cycle and causes sporadic cases or small outbreaks in rural areas. However, little is known about the influence of the environment on its transmission.
Abdourahmane Sow, Birgit Nikolay, Oumar Faye, Simon Cauchemez, Jorge Cano, Mawlouth Diallo, Ousmane Faye, Bakary Sadio, Oumar Ndiaye, Scott C. Weaver, Anta T. Dia, Amadou Alpha Sall, Denis Malvy   +12 more
doaj   +1 more source

Surveillance of the major pathogenic arboviruses of public health concern in Gabon, Central Africa: increased risk of West Nile virus and dengue virus infections

BMC Infectious Diseases, 2021
Background Increasing arbovirus infections have been a global burden in recent decades. Many countries have experienced the periodic emergence of arbovirus diseases. However, information on the prevalence of arboviruses is largely unknown or infrequently
Yuri Ushijima, Haruka Abe, Georgelin Nguema Ondo, Rodrigue Bikangui, Marguerite Massinga Loembé, Vahid R. Zadeh, Joseph G. E. Essimengane, Armel V. N. Mbouna, Emmanuel B. Bache, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda   +11 more
doaj   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

Advanced Intelligent Discovery, EarlyView.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki, Bassam Bachour Junior, Marcelo Mulato, José Ilton de Oliveira Filho   +3 more
wiley   +1 more source

Arbovirus infections incidence in the south of the European part of the Russian Federation

Журнал микробиологии, эпидемиологии и иммунобиологии, 2021
Purpose: analysis of the arbovirus infections incidence in the south of the European part of the Russian Federation in 2015–2019.Materials and methods.
N. F. Vasilenko, D. A. Prislegina, O. V. Maletskaya, T. V. Taran, A. E. Platonov, A. N. Kulichenko   +5 more
doaj   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

What are the vector species of the Oropouche virus?

Pest Management Science, EarlyView.
Here, we review the timeline of Oropouche virus (OROV) detection in various hematophagous Diptera, from 1955 to date, including mosquitoes and midges. All vector competence experiments also are described. The results suggest that Culicoides are the primary vectors.
Constância Flávia Junqueira Ayres, Bruna Lais Sena do Nascimento, Daniele Barbosa de Almeida Medeiros, Joaquim Pinto Nunes Neto   +3 more
wiley   +1 more source

Eco-epidemiologia dos arbovírus na área de influência da rodovia Cuiabá-Santarém (BR 163), Estado do Pará, Brasil Arbovirus eco-epidemiology in the area affected by the Cuiabá-Santarém Highway (BR-163), Pará State, Brazil

Cadernos de Saúde Pública, 2009
O presente estudo descreve os aspectos eco-epidemiológicos sobre arbovírus nos Municípios de Novo Progresso e Trairão, Estado do Pará, Brasil, na área de influência da BR 163.
Marcio Roberto Teixeira Nunes, Taciana Fernandes Souza Barbosa, Lívia Medeiros Neves Casseb, Joaquim Pinto Nunes Neto, Nazaré de Oliveira Segura, Hamilton Antônio de Oliveira Monteiro, Eliana Vieira Pinto, Samir Mansour Casseb, Jannifer de Oliveira Chiang, Lívia Caricio Martins, Daniele Barbosa de Almeida Medeiros, Pedro Fernando da Costa Vasconcelos   +11 more
doaj   +1 more source