Results 131 to 140 of about 174,264 (291)

Microbial diversity in Baltic Sea sediments [PDF]

, 2007
This thesis focuses on microbial community structures and their functions in Baltic Sea sediments. First we investigated the distribution of archaea and bacteria in Baltic Sea sediments along a eutrophication gradient.
Edlund, Anna
core  

Microbiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing

European Journal of Haematology, EarlyView.
ABSTRACT The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce.
Rafael Hernani, Eliseo Albert, Carlos Hernani‐Morales, Sheila Zúñiga, Ana Benzaquén, Laura González‐Castillo, Ester Colomer, Júlia Morell, José Francisco Català‐Senent, José Luis Piñana, Estela Giménez, Ariadna Pérez, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Marcos Rivada, Teresa Barber, Teresa Alemany, Enric Santacatalina, Pilar Rentero‐Garrido, María José Terol, Rafael Díaz, David Navarro, Carlos Solano   +22 more
wiley   +1 more source

Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein

The FEBS Journal, EarlyView.
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley   +1 more source

Erratum for Manoharan et al., “Metagenomes from Coastal Marine Sediments Give Insights into the Ecological Role and Cellular Features of Loki- and Thorarchaeota”

mBio, 2019
Lokeshwaran Manoharan, Jessica A. Kozlowski, Robert W. Murdoch, Frank E. Löffler, Filipa L. Sousa, Christa Schleper   +5 more
doaj   +1 more source

Multi-omic stock of surface ocean microbiome built by monthly, weekly and daily sampling in Dapeng Bay, China

Scientific Data
The coastal ocean is the dynamic interface where terrestrial, atmospheric, and marine systems converge, acting as a hotspot for microbial activity, which underpins the intricate web of carbon and nitrogen cycling.
Yanwei Chen, Siruo Chen, Jianchang Tao, Minxu Li, Wenxiu Wang, Mei Chen, Xiaochen Fang, Lingchao Kong, Yidong Wang, Olivier Pereira, Chuanlun Zhang   +10 more
doaj   +1 more source

Modulation of Hachiman defence by a type II toxin-antitoxin system via balancing trade-off between the fitness cost and antiphage activity

Engineering Microbiology
Hachiman systems provide innate antiphage immunity across prokaryotic domains. The system encodes a HamA nuclease and a HamB helicase both of which exhibit great diversity in sequence.
Xuhui Tian, Ruyi Zheng, Xin Li, Suping Jiang, Fang Wang, Yulong Shen, Qunxin She   +6 more
doaj   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

The FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti   +11 more
wiley   +1 more source

A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry

Nature Communications
Archaeal membrane lipids are markedly distinct from those in bacteria and eukaryotes, serving as biomarkers for unraveling their ecological and biogeochemical roles.
Fengfeng Zheng, Wenyong Yao, Wei He, Wan Zhang, Yufei Chen, Huahui Chen, Zhirui Zeng, Xiao-Lei Liu, Su Ding, Yanhong Zheng, Linan Huang, Yuanqing Zhu, Chuanlun Zhang   +12 more
doaj   +1 more source

Characterisation of a cold‐adapted, thermostable glucokinase from psychrophilic Pseudoalteromonas sp. AS‐131 reveals how the enzyme achieves high thermal stability without loss of cold adaptation

The FEBS Journal, EarlyView.
We investigated glucokinase from the psychrophilic Pseudoalteromonas sp. AS‐131 (PsGK), which was isolated from the Antarctic Ocean. Biochemical studies revealed that PsGK is a cold‐adapted enzyme with high thermal stability, in contrast to general cold‐adapted enzymes, which have low thermal stability.
Akane Yato, Yuki Kato, Fuyuko Hayashi, Rio Asaka, Atsuko Ogawa, Tokuro Oda, Sayaka Tsuji, Masashi Unno, Nobuaki Soh, Keiichi Watanabe, Masaki Horitani   +10 more
wiley   +1 more source

Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome

The FEBS Journal, EarlyView.
Ulvan is a polysaccharide available from green seaweed with beneficial properties for various applications. The full potential of ulvan requires enzymatic degradation of the polymer, thus producing ulvan oligosaccharides. This study expands the armoury of characterised ulvan lyases.
Andrius Jasilionis, Pavithra Sivakumar, Justyna M. Dobruchowska, Sune Fjermedal, Hörður Guðmundsson, Bjorn Thor Adalsteinsson, Guðmundur Ó. Hreggviðsson, Anne S. Meyer, Eva Nordberg Karlsson   +8 more
wiley   +1 more source