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Archetypal Analysis for population genetics. [PDF]

open access: yesPLoS Computational Biology, 2022
The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse ...
Julia Gimbernat-Mayol   +4 more
doaj   +4 more sources

Unravelling the instability of mutational signatures extraction via archetypal analysis [PDF]

open access: yesFrontiers in Genetics, 2023
The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts.
Corrado Pancotti   +5 more
doaj   +2 more sources

Combining electro- and magnetoencephalography data using directional archetypal analysis [PDF]

open access: yesFrontiers in Neuroscience, 2022
Metastable microstates in electro- and magnetoencephalographic (EEG and MEG) measurements are usually determined using modified k-means accounting for polarity invariant states.
Anders S. Olsen   +6 more
doaj   +2 more sources

A configurational approach to leadership behavior through archetypal analysis [PDF]

open access: yesFrontiers in Psychology, 2023
The behavioral approach to leadership, which has introduced leadership styles, has been of great importance to the leadership field. Despite its importance, scholars have recently argued and demonstrated that these styles have various conceptual ...
Janka I. Stoker   +3 more
doaj   +2 more sources

Archetypal Analysis and DEA Model, Their Application on Financial Data and Visualization with PHATE [PDF]

open access: yesEntropy, 2022
One of the goals of macroeconomic analysis is to rank and segment enterprises described by many financial indicators. The segmentation can be used for investment strategies or risk evaluation. The aim of this research was to distinguish groups of similar
Urszula Grzybowska, Marek Karwański
doaj   +2 more sources

Convex Representations Using Deep Archetypal Analysis for Predicting Glaucoma [PDF]

open access: yesIEEE Journal of Translational Engineering in Health and Medicine, 2020
Goal: The purpose of this study was to identify clinically relevant patterns of glaucomatous vision loss through convex representation to predict glaucoma several years prior to disease onset.
Anshul Thakur   +2 more
doaj   +2 more sources

Non-linear archetypal analysis of single-cell RNA-seq data by deep autoencoders. [PDF]

open access: yesPLoS Computational Biology, 2022
Advances in single-cell RNA sequencing (scRNA-seq) have led to successes in discovering novel cell types and understanding cellular heterogeneity among complex cell populations through cluster analysis.
Yuge Wang, Hongyu Zhao
doaj   +2 more sources

Archetypal analysis of COVID-19 in Montana, USA, March 13, 2020 to April 26, 2022. [PDF]

open access: yesPLoS ONE
Infectious disease data can often involve complex spatial patterns intermixed with temporal trends. Archetypal Analysis is a method to mine complex spatio-temporal data, and can be used to discover the dynamics of spatial patterns.
Emily Stone   +2 more
doaj   +2 more sources

From Spider-Man to Hero — Archetypal Analysis in R [PDF]

open access: yesJournal of Statistical Software, 2009
Archetypal analysis has the aim to represent observations in a multivariate data setas convex combinations of extremal points. This approach was introduced by Cutler andBreiman (1994); they dened the concrete problem, laid out the theoretical ...
Manuel J. A. Eugster, Friedrich Leisch
doaj   +1 more source

Chrysalis: decoding tissue compartments in spatial transcriptomics with archetypal analysis [PDF]

open access: yesCommunications Biology
Dissecting tissue compartments in spatial transcriptomics (ST) remains challenging due to limited spatial resolution and dependence on single-cell reference data.
Demeter Túrós   +4 more
doaj   +2 more sources

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