Results 211 to 220 of about 37,709 (292)

Operational intelligence for immunization recovery: mapping system shocks and capacity to zero-dose debt and outbreak risk. [PDF]

Front Health Serv
Ramakrishnan S, Vignesh U, Parvathi R.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Pathways of emergency care for severely ill children in Nigerian and Ugandan hospitals: A process mapping study. [PDF]

PLoS Med
Subhi R, Sogbesan A, Muramuzi D, Burhin M, Bakare AA, Falade AG, Kitutu FE, Ssengooba F, King C, Kane S, Dawson-McClaren B, Graham HR, MOXY-Implementation Research Collaboration.   +12 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Evaluating the impact of antiviral post-exposure prophylaxis for health-care workers during ebolavirus outbreaks: a modelling study

Stapley JN, Ko Y, Jeyapragasan G, Chan EM, Walekhwa AW, Mills C, Fraser C, Reingold AL, Ebengo D, Donnelly CA, Mbala PK, Whittaker C.   +11 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Multimodal Patient-Specific Identification of Atrial Flutter Circuits From ECG Time Series Using Explainable Machine Learning. [PDF]

IEEE J Transl Eng Health Med
Ruiperez-Campillo S, Hernando D, Ramirez E, Castrejon S, Zapata C, Carneiro CR, Vogt JE, Merino JL, Castells F, Millet J.   +9 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer. [PDF]

Nat Commun
Weng S, Cain L, Comben J, Zhang Y, Semple T, Alaei S, Yoannidis D, Martelotto L, Mitchell C, Pasam A, Young RJ, Blyth B, Hendley J, Feng Y, Thorne H, Wallace R, Chan J, Como J, Devereux L, Beltran H, Wetterskog D, Williams S, Papenfuss AT, Parker B, Neeson P, Attard G, Quigley D, Goode DL, Pearson RB, Furic L, Trigos AS, Sandhu S.   +31 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source