Results 231 to 240 of about 186,906 (370)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
THE EVOLUTION OF ARCHETYPAL STRUCTURE IN ADYGHE HISTORICAL-HEROIC EPIC
, 2019 A.M. Gutov
openalex +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
The Rise of the Knowledge Sculptor: A New Archetype for Knowledge Work in the Age of Generative AI
Cathal Doyle
openalex +1 more source
Stalin saves the world — Stalin and the evolution of the Warrior and Saviour archetypes
, 2016 openalex +1 more source
Tropical dry woodland loss in India since 1880 and its relation to current megafauna distributions. [PDF]
Ecol ApplKalam T +6 more
europepmc +1 more source
Representing Style by Feature Space Archetypes: Description and Emulation of Spatial Styles in an Architectural Context [PDF]
, 2006 Hanna, S
core
FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source