Results 91 to 100 of about 96,820 (273)

An Online Tutor for Astronomy: The GEAS Self-Review Library

, 2015
We introduce an interactive online resource for use by students and college instructors in introductory astronomy courses. The General Education Astronomy Source (GEAS) online tutor guides students developing mastery of core astronomical concepts and ...
Muise, Amy Smith, Vogt, Nicole P.
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

THE PLOT OF THE FOOL’S INITIATION IN THE NOVEL BY L. N. TOLSTOY “THE COSSACKS”

Филологический класс, 2019
The functions of the initiation plot in the novel by L. N. Tolstoy “The Cossacks” are considered in the artistic paradigm of the archetype of the Fool – one of the key figures of a folk tale whose traits are clearly readable in the structure of the ...
doaj   +1 more source

A Generative Model of Group Conversation

, 2017
Conversations with non-player characters (NPCs) in games are typically confined to dialogue between a human player and a virtual agent, where the conversation is initiated and controlled by the player.
Martens, Chris, Morrison, Hannah
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

THE CHARACTER OF REYNARD THE FOX IN THE CHILDREN’S LITERATURE OF FRANCE, GERMANY AND LUXEMBURG (SECOND HALF OF THE 20TH – BEGINNING OF THE 21ST CENTURIES)

Филологический класс, 2019
The article focuses on the variants of representation and author’s interpretation of the title character of the medieval fables “Reynard the Fox” in the children’s literature of three countries.
doaj   +1 more source

The Role of the Unconscious in the Perception of Risks [PDF]

, 1995
Dr. Fritzsche argues that our world is too rational and that the psychology of the unconscious, as developed by Jung, can be key to understanding responses to hazards and to resolving conflicts that arise in the political management of ...
Fritzsche, Andrew F.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Archetypes of community-based pond aquaculture in Indonesia: applying the social-ecological systems framework to examine sustainability tradeoffs

Environmental Research Letters
We analyze archetypes of farmer groups conducting pond aquaculture across the province of Nusa Tenggara Barat, Indonesia using Ostrom’s social-ecological systems framework.
Ben Nagel, Nurliah Buhari, Stefan Partelow   +2 more
doaj   +1 more source

Locke's Criterion for the Reality of Ideas: Unambiguous but Untenable [PDF]

, 1997
The paper argues against the claim held, e.g., by Leibniz, that Locke employs a double standard for determining whether an object before the mind (i.e., an idea) is real.
de Waal, Cornelis
core