Results 111 to 120 of about 23,461 (309)
Modeling with System Archetypes
, 2008 This chapter examines the application of system archetypes as a systems development methodology to create simulation models. Rapid organizational change and need to adapt to new business models limits the lifespan of both the databases and software ...
Mahendran Maliapen
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Analysis of Instinctive Human Behavior through Archetypes in The Menu (2022) Film
This research aims to analyze how the archetypes according to Carl Gustav Jung are representedin embodying behavior and underlying human experience. This research uses the archetypaltheory by Carl Gustav Jung to answer research questions regarding the ...
akhmad zakky, Anzalas Sakinata
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Archetypes of Strategy Formulation
There have been few attempts to understand the strategy making process by examining the organizational and environmental context in which it occurs. Rather than adopting the stance of contingency theorists who focus mainly on bivariate relationships, we ...
Peter H. Friesen, Danny Miller
core +1 more source
An examination of the mythological allusions in Alex Michaelides’ The Silent Patient and The Maidens
Cogent Arts & HumanitiesThe present study examines the use of myths in Alex Michaelides’ The Silent Patient (2019) and The Maidens (2021). It is argued that Alicia’s silence in The Silent Patient not only parallels Alcestis’ silence but also empowers Alicia to achieve justice ...
Nisrein M. Abu Sawa
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Culture and IS: A criticism of predefined cultural archetypes studies
, 2008 Although there are many different models of national culture, most IS research has tended to rely almost solely on Hofstede’s cultural model (Keil et al., 2000; Straub, 1994; Tan et al., 1995; Watson et al., 1994; Myers and Tan, 2002; Kirkman et al. 2006)
Brooks, L, Ali, M, Alshawi, S
core
The Cultural Heritage of Turkic Peoples in Kazakh Cinema: Intersecting Worlds
Conservation Science in Cultural HeritageThe aim of the study is to analyze Kazakh and proto-Turkic myths, and mythological aspects in Kazakh cinema, and to assess the influence of other aspects, such as film language and semiotics on film direction and the status of Kazakh cinema in a global ...
Kholganat Murat +4 more
doaj +1 more source