Results 111 to 120 of about 7,406 (265)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Archetypal analysis of pain measures in a diverse population-based cohort: Exploring cross-sectional relationships with outcomes. [PDF]

Osteoarthr Cartil Open
Pazooki P, Arbeeva L, Tomar S, Alvarez C, Walker T, Golightly YM, Lascelles BDX, Nelson AE.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A cross-platform transcriptomic risk score integrating LymphoMAP microenvironment archetypes and immune evasion-associated programs in diffuse large B-cell lymphoma. [PDF]

Oncol Lett
Chen X, Zhang J, Jin S, Wang L, Zhang Y.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Eigenvalue Ratios Reveal Shared Binding Pocket Shapes in RNA and Protein Structures. [PDF]

Comput Struct Biotechnol J
Ziani L, Badel A, Dufay L, Flatters D, Regad L, Camproux AC.   +5 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Using systems archetypes to understand system behaviour and identify leverage points for change in local obesity prevention in The Netherlands. [PDF]

Health Promot Int
O'Mara J, Crielaard L, Hagenaars L, Stronks K, Waterlander W.   +4 more
europepmc   +1 more source

Does AI communication strategy matter for health persuasion? Comparing three archetypes in visual health education. [PDF]

Front Psychol
Zuo C, Pan Y, Guo R, Liang M, Zhang Y, Xia Y, Kong Y.   +6 more
europepmc   +1 more source

Developing curriculum archetypes as a reflective tool for health professions educators: a qualitative study. [PDF]

BMC Med Educ
Nasri N, Jamaludin KA, Mohamad Nasri N.
europepmc   +1 more source