Results 121 to 130 of about 23,461 (309)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Наукові записки Наукма: Історія і теорія культуриThe article examines how archetypes are manifested in the image of V. Zelenskyy. A general description of the archetypes of persona, shadow, sage, child, trickster in the works of C. Jung is given. The relationship between the features of gods and titans
Oles’ Dovhanyk
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Parallel Program Archetypes [PDF]
, 1997 A parallel program archetype is an abstraction that captures the common features of a class of problems with similar computational structure and combines them with a parallelization strategy to produce a pattern of dataflow and communication.
Massingill, Berna L., Chandy, K. Mani
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Archetypes : Common systemic behaviours in food systems
, 2018 System archetypes represent generic behavioural patterns – or system dynamics – in any system. The concept of archetypes is mostly applied in the context of business management and organizational life.
Steenhuijsen-Piters, Bart, de +4 more
core +2 more sources
O descoperire arheologică unică la Noviodunum: arhetipuri, tipare şi producerea opaiţelor [PDF]
Peuce, 2016 Noviodunum fortress, identified approx 2 km NW of the town of Isaccea, on the Danube’s left bank, became a landmark for the Roman and Roman-Byzantine period, due to both numerous historic sources and to archaeological finds that drew the picture of its ...
Florin TOPOLEANU, Laurent CHRZANOVSKI
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Archetypes inform our self-image, influence how we see the world, and direct many of the actions we take as we navigate and create our realities. According to psychologist Carl G.
Mike Sosteric
core +1 more source