Results 141 to 150 of about 23,461 (309)
Archetypes, Synchronicity, and Meaning Formation [PDF]
Archetypes and synchronicities are often treated as symbolic, cultural, or metaphysical phenomena. This paper offers a structural account in which both arise as downstream expressions of meaning formation within a single cognitive system.
Davidson, Y.
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Gender Effects in Perceiving Advertising Archetypes
, 2016 This study will examine the gender effects in perceiving advertising archetypes. Our society is constantly becoming more and more media saturated, and advertisers need to focus on employing evidence-based strategies to reach their target audiences.
Shipman, Sabrah
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Anti-Archetypes: Systemic stories of hope [PDF]
, 2019 Positive stories of change can play a powerful role in shaping systems. In systems-thinking, stories can take the form of systems archetypes which depict recurring themes and organizational dramas.
Zaidi, Leah
core
Brünner Beiträge zur Germanistik und Nordistik, 2013 Knut Hamsun was a very popular writer between the two world wars in many countries. It was also during this period that the first and only monograph in the Czech language on Hamsun's life and works was written.
Martin Humpál
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Archetypes are mental structures that are shared among members of a species. They are thought to be innate rather than learnt, and help individuals make sense of and decide what to do about the world.
KOH, Ivy H. Y., LI, Norman P.
openaire +4 more sources
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source