Results 71 to 80 of about 96,820 (273)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Conditioned emergence: a dissipative structures approach to transformation [PDF]

, 1999
This paper presents a novel framework for the management of organisational transformation, defined here as a relatively rapid transition from one archetype to another.
Aaker, Ancona, Armstrong, Bagozzi, Bagozzi, Bourgeois, Bourgeois, Bourgeois, Bourgeois, Burns, Child, Cronbach, Dess, Dess, Dess, Dess, Dess, Doty, Duncan, Enz, Finkelstein, Floyd, Fornell, Galbraith, Ginsberg, Gladstein, Govindarajan, Griffin, Grinyer, Hambrick, Hambrick, Hart, Hax, Hinings, Hrebiniak, Iaquinto, Irving, Jehn, Katz, Kim, Lawrence, Li, Miles, Miller, Miller, Miller, Milliken, Naman, Nunnally, Pelled, Porter, Porter, Porter, Priem, Ruekert, Ruekert, Rumelt, Schoonhoven, Schweiger, Sharma, Skivington, Song, Stagner, Thompson, Tjosvold, Tushman, Venkatraman, Venkatraman, Walker, West, Whitney, Wooldridge, Zajac   +72 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Archetypes

Archetypes are mental structures that are shared among members of a species. They are thought to be innate rather than learnt, and help individuals make sense of and decide what to do about the world.
KOH, Ivy H. Y., LI, Norman P.
  +6 more sources

Advertising between Archetype and Brand Personality

Administrative Sciences, 2016
The aim of the paper is the alignment of C.G. Jung’s (1954) archetypes and Aaker’s (1997) brand personality framework in the context of advertising. C.G. Jung’s theories had a tremendous impact on psychology.
Clemens Bechter, Giorgio Farinelli, Rolf-Dieter Daniel, Michael Frey   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Unsupervised Learning of Artistic Styles with Archetypal Style Analysis [PDF]

, 2018
In this paper, we introduce an unsupervised learning approach to automatically discover, summarize, and manipulate artistic styles from large collections of paintings.
Mairal, Julien, Schmid, Cordelia, Wynen, Daan   +2 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

From James Bond with love: tourism and tourists in the Bond saga

Via@, 2018
‘We could meet at the Saint Sophia mosque. – Like we were tourists,’ suggests James Bond to Russian agent Tatiana Romanova in From Russia with Love. Since 1962 and the release of Dr.
Marie-Hélène Chevrier, Chloé Huvet
doaj   +1 more source