Results 131 to 140 of about 135,513 (312)

Analysis of U.S. Senate Web Sites For Disability Accessibility [PDF]

open access: yes, 2009
U.S. federal government web sites have increased significantly the level of services and information offered to various internal and external stakeholders.
Dolechek, R.   +4 more
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

The Baptist Church in Warren: Rehabilitation and Preservation Report [PDF]

open access: yes, 2013
The Baptist Church in Warren is located in the Warren Waterfront Historic National Register District. Warren also has a Voluntary Historic District. Both the National Register Nomination and the Voluntary Historic District have regulations which pertain ...
Bambara, Lauren   +4 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Digitally Archiving Architectural Models and Exhibition Designs: The Case of an Art Museum [PDF]

open access: yes, 2015
[Excerpt] In 2013, a medium-sized art museum located in the Northeast United States received a grant to plan for an electronic records repository. This museum will be referred to here as USAM for brevity.
Cocciolo, Anthony
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Implications of privacy needs and interpersonal distancing mechanisms for space station design [PDF]

open access: yes
Privacy needs, or the need of people to regulate their degree of contact with one another, and interpersonal distancing mechanisms, which serve to satisfy these needs, are common in all cultures.
Harrison, A. A.   +3 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Analysing how constraints impact architectural decision-making [PDF]

open access: yes, 2015
Architectural design projects are characterised by a high number of constraints. Along with planning, energy performance and fire safety regulations, current designers have to face constraining factors related to budget, acoustics, orientation, wind ...
De Meyer, Ronald   +2 more
core   +1 more source

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