Results 111 to 120 of about 135,513 (312)

The Ambient Networks Heterogeneous Access Selection Architecture

open access: yes, 2007
Proc. First Ambient Networks Workshop on Mobility, Multiaccess, and Network Management (M2NM), Sydney, Australia, October 2007, pp.
Pentikousis, Kostas   +5 more
openaire   +3 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

The impact of inclusive architectural strategies on social inclusion characteristics in innovation hubs in Southwest Nigeria

open access: yesFrontiers in Built Environment
Innovation hubs foster collaboration, creativity, and economic growth. However, the inclusivity of these spaces remains a critical factor in ensuring equal access and participation by diverse users.
Eghosa Noel Ekhaese, Felicia Oyelude
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Towards an understanding of corporate web identity [PDF]

open access: yes, 2014
No abstract ...
Elliott, C., Robinson, S.
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

An ontology-based MDA framework for service-based software systems architecting [PDF]

open access: yes, 2005
Model-driven Architecture (MDA) is a software architecture framework proposed by the Object Management Group OMG. MDA emphasises the importance of modelling in the architectural design of software systems.
Pahl, Claus
core  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

The key performance indicators of the BIM implementation process [PDF]

open access: yes, 2010
Contemporarily some firms in the construction industry are attempting to adopt a BIM method of working. Each of these attempts reflects a varying BIM adoption philosophy and inevitably different BIM technologies, implementation strategies and roadmaps ...
Arayici, Y   +5 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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