Results 91 to 100 of about 135,513 (312)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Data Access-Centered Understanding of Microservices Architectures [PDF]
2025 IEEE 22nd International Conference on Software Architecture Companion (ICSA-C)Recent studies show that developers encounter difficulties when evolving microservices architectures, especially from a code and data management perspective. Specifically, they struggle to recover a high-level view, although essential for understanding and maintaining complex interactions across various microservices codebases and their databases. This
André, Maxime +3 more
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Physical performance and durability evaluation of rubberized concrete [PDF]
, 2014 The main objective of this research is to develop rubberized concrete with achievable structural strength using simple mix design. Simple mix design is a description by using the crumb rubber, used as in condition just received from the plant without
Md Noor, Nurazuwa
core
Achieving the state of research pertaining to GIS applications for cultural heritage by a systematic literature review [PDF]
, 2018 During the last decade, we have witnessed an increased interest in Geographic Information Systems (GIS), including the so-called “Historical GIS”, 3D GIS heritage and its subcategory of “SDI for cultural heritage”.
Ferreira Lopes, Patricia
core +3 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Universal Design: Planning and Design for All [PDF]
, 1997 [Excerpt] This report attempts to develop and illustrate the concept of universal design. The aim of universal design is to develop theory, principles and solutions to enable everybody to use the same physical solutions to the greatest extent possible ...
Aslaksen, Finn +3 more
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
BIM adoption and implementation for architectural practices [PDF]
, 2011 Severe issues about data acquisition and management arise during the design creation and development due to complexity, uncertainty and ambiguity. BIM (Building Information Modelling) is a tool for a team based lean design approach towards improved ...
Arayici, Y +5 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source