Results 71 to 80 of about 19,172 (304)
, 2021 Venice is a singular city in which its “fragile” heritage is closely linked to the complex ur- ban morphology. In the city, there are a significant number of urban obstacles – such as bridges, differences in level, narrow “calli” and unprotected canal ...
Valeria Tatano, Rosaria Revellini
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Публічне управління та регіональний розвитокThe article analyzes the experience of foreign countries in the field of architectural accessibility for people with limited mobility and the possibilities of its adaptation in Ukraine.
Svitlana Surgova, Olena Faichuk
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Accessibility and sensory experiences: designing dwellings for the visual and hearing impaired
, 2013 This article introduces a new design concept; sensory accessibility. While acknowledging the importance of sensory design and experiences in architectural quality, as well as the importance of accommodating user needs in design, the concept combines ...
Ryhl, Camilla
core
Parallel Memory Accessing for FFT Architectures
Journal of Signal Processing Systems, 2018 The current paper introduces an efficient technique for parallel data addressing in FFT architectures performing in-place computations. The novel addressing organization provides parallel load and store of the data involved in radix-r butterfly computations and leads to an efficient architecture when r is a power of 2. The addressing scheme is based on
V. Kitsakis +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Reality check: Notions of accessibility in today’s architectural design practice
, 2014 Understandings of accessibility evolved from focusing on wheelchair accessibility to more integrated notions like inclusive design, according to which everybody should be able to use space in an equitable and independent way.
Wauters, Hannelore +2 more
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source