Results 61 to 70 of about 15,745 (300)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Understanding the Spatial Needs of Transgender Individuals

Enquiry: The ARCC Journal of Architectural Research
This study investigates the spatial requirements of transgender individuals in urban and sacred contexts, with particular reference to pilgrimage sites in Saundatti.
Sheetal Lad, Kavita Murugkar
doaj   +3 more sources

Constrains and barriers of implementing sustainability into architectural professional practice in Jordan

Alexandria Engineering Journal, 2019
Sustainable buildings created a challenge for architectural professional practice in Jordan, and no doubt that there are many obstacles to the widespread of implementing sustainable building practices.
Hikmat H. Ali, Ayat A. Alkayed
doaj   +1 more source

Architectural design principles and processes for sustainability : towards a typology of sustainable building design

, 2011
The shift towards sustainable buildings requires a transformation of the architectural design process. This paper examines how sustainability is embedded into design methodology and mapped onto, or has transformed, the design process in practise ...
Grierson, David, Moultrie, Carolyn Mary
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Architectural Barriers to the Handicapped

, 1979
Edward C.Viner '79 works on his project about architectural barriers to the ...
unknown
core  

A configurational approach to the dynamics of firm level knowledge [PDF]

, 2009
Whilst there has been exponential growth in the work on the nature of organisational knowledge, relatively little progress has been made in terms of understanding the way in which knowledge specifically impacts on the firm. The aim of this paper is to
Ambrosini, Veronique, Collier, Nardine, Collier, N, Jenkins, M, Jenkins, Mark   +4 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Exploring Metaverse Integration in Architectural Education for Immersive Learning and Creativity [PDF]

Computer and Knowledge Engineering
In response to the evolving demands of architectural education in the digital age, this study explores the transformative potential of the metaverse as a pedagogical platform.
Mahdi Motamedmanesh, Parisa Mirjalili, Azin Pourseyedi   +2 more
doaj   +1 more source

A Governance Method for Overcoming Cloud Computing Barriers with Architectural Requirements: Mixed Method Study Based on the Government Cloud in Saudi Arabia

, 2020
Despite the promising application of cloud computing within government organisations, determining the barriers to the successful implementation of cloud computing remains a major challenge.
Alghamdi, Bader A
core   +1 more source