Results 61 to 70 of about 48,265 (304)
Essay: Hanoi: La Folie des Grandeurs [PDF]
Pacific Geographies, 2019 Around the time Admiral Charles Rigault de Genouilly, under the orders of Emperor Napoléon III, fired the first canon shots to lay claim to what would become France’s colony of Indochina, Paris embarked on an epic renovation project directed by Baron ...
Burchett, George
doaj +1 more source
Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase [PDF]
Nature Communications, 2015 AbstractRadical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluster to generate a 5′-deoxyadenosyl radical. Canonical radical SAM enzymes are characterized by a β-barrel-like fold and SAM anchors to the differentiated iron of the cluster, which is located near the amino terminus and within the β-barrel, through its amino and carboxylate groups ...
Fenwick, Michael K. +5 more
openaire +2 more sources
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Miejsce ekfrazy w bizantynistycznej historiografii artystycznej
Vox Patrum, 2018 In Byzantium, writing ekphrases was one of the standard literary skills, developed during school instruction. Yet, in Byzantine art history, the analysis of Byzantine ekphrases had long been beyond the scope of researchers who favoured rather the ...
Małgorzata Smorąg Różycka
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Modernist Architecture and Ruins [PDF]
, 2019 Modernist Architecture and Ruins: On Ruins as a Minus, Neoclassicism and the ...
Kurir, Mateja
core
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
At hylde arkitekturen. Bygningspræmiering som kritisk praksis
Periskop, 2019 Architectural critique is often considered to be in a long-term crisis. Suggested causes are theoretical changes to the role of the critic, as well as reviews being expelled from a changing media landscape.
Martin Søberg, Morten Birk Jørgensen
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Revealing the Archetype: The Journey of a Trecento Madonna and Child at the National Museum of Scotland [PDF]
, 2017 The National Museums Scotland Madonna and Child project sought to uncover and document the history of a fine polychrome wood carving attributed to The Master of the Gualino St Catherine and to prepare it for display. A new body of knowledge has been
Challands, T. +7 more
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