Results 41 to 50 of about 28,060 (247)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Agrarian voids as dynamic spaces in the contemporary city. The historic orchards of Nerja, Malaga

Ri-vista: Ricerche per la Progettazione del Paesaggio
Agriculture and architecture are realities in continuous dialogue in many territories where the productive landscape is an inherent part of the built environment, especially those on a smaller scale with an immediate presence in the city, such as the ...
Celia Chacón Carretón, Mar Loren-Méndez, Pablo Millán-Millán   +2 more
doaj   +1 more source

Polvese Chapels. The Sense of the Sacred in Nine Offline Places

In_Bo, 2022
The concept of the sacred can be perhaps broadened by comparing it with its opposite, revealing new meanings. If the term profane etymologically refers to the need to “stand outside the temple” (from the Latin pro-fanus, literally “in front of the temple”
Paolo Belardi, Massimiliano Marianelli, Giovanna Ramaccini, Monica Battistoni, Margherita Maria Ristori, Camilla Sorignani   +5 more
doaj   +1 more source

WINE CULTURAL LANDSCAPE AND VERNACULAR TYPOLOGIES IN SOUTH-WESTERN IBERIA: THREE CASE STUDIES IN ALENTEJO AND ANDALUSIA [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020
In the Mediterranean scenery of the south-western Iberian Peninsula, vineyards and wine-making have consistently been key pieces of the man-made cultural landscape, influencing urban design and even housing.
A. C. Rosado, A. C. Rosado, J. M. Aladro-Prieto, M. T. Pérez-Cano   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

THE ACADEMY OF FINE ARTS GARDEN IN THE SYSTEM OF ACADEMIC QUARTER PUBLIC SPACES: CHAPTERS OF HISTORY AND DEVELOPMENT PROSPECTS

Архитектон, 2022
The article presents the first ever analysis of the Academic Garden as part of the system of public spaces in the Academy of Fine Arts quarter. The role of the Academic Garden in the visual and spatial perception of the architectural composition of the ...
Vasilenko Andrey I.
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Unknown Suns: László Hudec, Antonin Raymond and the Rising of a Modern Architecture for Eastern Asia

Buildings, 2022
The purpose of this article is to disclose the strenuous efforts of László Hudec in China and Antonin Raymond in Japan and India to create a modern architectural stance by heralding an incipient space syntax. At the turn of the 19th century, for dynastic,
Anamaria Andreea Anghel, Joseph Cabeza-Lainez, Yingying Xu   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source